ArticlePloS one2015
Helicobacter pylori Infection in Thailand: A Nationwide Study of the CagA Phenotype.
Article in PloS one, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers.
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29 citing papers in PubMed, 57 citations in OpenAlex.
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- Relationship between Helicobacter Pylori Infection and the Risk of Esophageal Cancer in Thailand.Asian Pacific journal of cancer prevention : APJCP · 2023Article
- Serum pepsinogen level as a biomarker for atrophy, reflux esophagitis, and gastric cancer screening in Indonesia.Journal of research in medical sciences : the official journal of Isfahan University of Medical Sciences · 2022Article
- Diversity of 3' variable region of cagA gene in Helicobacter pylori strains isolated from Chinese population.Gut pathogens · 2021Article
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- Association between renal function and co-infection with Clonorchis sinensis and Helicobacter pylori: a cross-sectional study.BMC infectious diseases · 2020Article
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- Serum pepsinogens as a gastric cancer and gastritis biomarker in South and Southeast Asian populations.PloS one · 2020Article
- Interleukin-8 associated with chemosensitivity and poor chemotherapeutic response to gastric cancer.Journal of gastrointestinal oncology · 2019Article
- High Efficacy of Rapid Urine Test for Diagnosis of Helicobacter pylori Infection in Thai PeopleAsian Pacific journal of cancer prevention : APJCP · 2019Article
- CYP2C19 Genotype, CagA Genotype and Antibiotic Resistant Strain of Helicobacter pylori InfectionAsian Pacific journal of cancer prevention : APJCP · 2019Article
- Analysis of risks of gastric cancer by gastric mucosa among Indonesian ethnic groups.PloS one · 2019Article
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- Molecular Epidemiology of Helicobacter pylori Infection in a Minor Ethnic Group of Vietnam: A Multiethnic, Population-Based Study.International journal of molecular sciences · 2018Article
Corrections and comments
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Authors and funding
10 authors at 7 institutions in 4 countries.
Funding
Abstract
backgroundThe risk to develop gastric cancer in Thailand is relatively low among Asian countries. In addition, the age-standardized incidence rate (ASR) of gastric cancer in Thailand varies with geographical distribution; the ASR in the North region is 3.5 times higher than that in the South region. We hypothesized that the prevalence of H. pylori infection and diversity of CagA phenotype contributes to the variety of gastric cancer risk in various regions of Thailand.
methodsWe conducted a nationwide survey within Thailand. We determined H. pylori infection prevalence by detecting H. pylori, using histochemical and immunohistochemical methods. The anti-CagA antibody and anti-East-Asian type CagA antibody (α-EAS Ab), which showed high accuracy in several East Asian countries, were used to determine CagA phenotype.
resultsAmong 1,546 patients from four regions, including 17 provinces, the overall prevalence of H. pylori infection was 45.9% (710/1,546). Mirroring the prevalence of H. pylori infection, histological scores were the lowest in the South region. Of the 710 H. pylori-positive patients, 93.2% (662) were immunoreactive with the anti-CagA antibody. CagA-negative strain prevalence in the South region was significantly higher than that in other regions (17.9%; 5/28; p < 0.05). Overall, only 77 patients (11.6%) were immunoreactive with the α-EAS Ab. There were no differences in the α-EAS Ab immunoreactive rate across geographical regions.
conclusionsThis is the first study using immunohistochemistry to confirm H. pylori infections across different regions in Thailand. The prevalence of East-Asian type CagA H. pylori in Thailand was low. The low incidence of gastric cancer in Thailand may be attributed to the low prevalence of precancerous lesions. The low incidence of gastric cancer in the South region might be associated with the lower prevalence of H. pylori infection, precancerous lesions, and CagA-positive H. pylori strains, compared with that in the other regions.
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