ArticleInternational journal of cancer2016
Body size across the life course and prostate cancer in the Health Professionals Follow-up Study.
Article in International journal of cancer, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers.
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Who cites it
27 citing papers in PubMed, 53 citations in OpenAlex.
- Prediagnostic Body Mass Index Trajectories in Relation to Prostate Cancer Incidence and Mortality in the PLCO Cancer Screening Trial.Journal of the National Cancer Institute · 2017Trial
- Obesity, metformin prescription and risk of advanced prostate cancer in non-diabetic men.BJC reports · 2026Article
- Review
- Modifiable risk factors for subsequent lethal prostate cancer among men with an initially negative prostate biopsy.British journal of cancer · 2023Article
- Review of Cardiovascular Risk of Androgen Deprivation Therapy and the Influence of Race in Men with Prostate Cancer.Cancers · 2023Review
- Diet and BMI Correlate with Metabolite Patterns Associated with Aggressive Prostate Cancer.Nutrients · 2022Article
- The Role of Mendelian Randomization Studies in Deciphering the Effect of Obesity on Cancer.Journal of the National Cancer Institute · 2022Article
- Longitudinal trajectories of lifetime body shape and prostate cancer angiogenesis.European journal of epidemiology · 2022Article
- Association of Anthropometric Measures With the Risk of Prostate Cancer in the Multiethnic Cohort.American journal of epidemiology · 2021Article
- Waist circumference and a body shape index and prostate cancer risk and mortality.Cancer medicine · 2021Article
- Body shape and pants size as surrogate measures of obesity among males in epidemiologic studies.Preventive medicine reports · 2020Article
- Body mass index trajectories and prostate cancer risk: Results from the EPICAP study.Cancer medicine · 2020Article
- Measures of body fatness and height in early and mid-to-late adulthood and prostate cancer: risk and mortality in The Pooling Project of Prospective Studies of Diet and Cancer.Annals of oncology : official journal of the European Society for Medical Oncology · 2020Article
- Obesity, height, and advanced prostate cancer: extending current evidence toward precision prevention.Annals of oncology : official journal of the European Society for Medical Oncology · 2020Article
- Relationship of self-reported body size and shape with risk for prostate cancer: A UK case-control study.PloS one · 2020Article
- Article
- Phytochemicals in Prostate Cancer: From Bioactive Molecules to Upcoming Therapeutic Agents.Nutrients · 2019Review
- Body mass index trajectories across adulthood and smoking in relation to prostate cancer risks: the NIH-AARP Diet and Health Study.International journal of epidemiology · 2019Article
- Obesity, Inflammation, and Prostate Cancer.Journal of clinical medicine · 2019Review
- The Epidemiology of Prostate Cancer.Cold Spring Harbor perspectives in medicine · 2018Review
Corrections and comments
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Authors and funding
6 authors at 2 institutions in 3 countries.
Funding
Abstract
Current evidence of an association between body size and prostate cancer is conflicting, possibly due to differential effects of body size across the lifespan and the heterogeneity of the disease. We therefore examined childhood and adult body size in relation to total incident prostate cancer and prognostic subtypes in a prospective cohort of 47,491 US men in the Health Professionals Follow-up Study. We assessed adult height, body mass index (BMI) in early and middle-to-late adulthood, adult waist circumference, and body shape at age 10. With follow-up from 1986 to 2010, we estimated the relative risk (RR) of prostate cancer using Cox proportional hazards models. We identified 6,183 incident cases. Tallness was associated with increased risk of advanced-stage tumors, particularly fatal disease (RR = 1.66, 95% CI 1.23-2.23, highest vs. lowest quintile, ptrend < 0.001). High BMI at age 21 was inversely associated with total prostate cancer (RR = 0.89, 95% CI 0.80-0.98, BMI ≥ 26 vs. 20-21.9, ptrend = 0.01) and with fatal and advanced disease. The association for late adult BMI differed by age (pinteraction < 0.001); high BMI was inversely associated with total prostate cancer (RR = 0.64, 95% CI 0.51-0.78, BMI ≥ 30 vs. 21-22.9, ptrend <0.001) and with non-advanced and less aggressive tumors among men ≤ 65 years, whereas no association was seen among men >65 years. Adult waist circumference was weakly inversely associated with less aggressive disease. Childhood obesity was unclearly related to risk. Our study confirms tall men to be at increased risk of fatal and advanced prostate cancer. The influence of adiposity varies by prognostic disease subtype and by age. The relationship between body size and prostate cancer is complex. Body size changes progressively throughout life and consequent effects on prostate cancer risk may be associated with related changes in hormonal and metabolic pathways. This large prospective study examined potential associations between the risk of various prostate cancer subtypes and multiple anthropometric measures at different ages in men. Tallness was confirmed to be associated with an elevated risk of advanced prostate cancer, particularly fatal disease. The extent to which body weight influenced risk varied according to factors such as age and disease subtype.
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