Evidence map›Paper›PMID 26355571›Full record

ArticleAIDS (London, England)2015

Stromal immune infiltration in HIV-related diffuse large B-cell lymphoma is associated with HIV disease history and patient survival.

Chun Chao, Lanfang Xu, Michael J Silverberg, Otoniel Martínez-Maza, Lie-Hong Chen, Brandon Castor, Donald I Abrams, Hongbin D Zha, Reina Haque, Jonathan Said

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in AIDS (London, England), 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed, 1 pooled it
0.4field-weighted citation impact, top 32% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 1 synthesis or guideline pooled it, 5 citations in OpenAlex.

  1. Pooled it
  2. Review
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 4 institutions in 1 country.

Chun ChaoaDepartment of Research and Evaluation, Kaiser Permanente Southern California, Pasadena bDivision of Research, Kaiser Permanente Northern California, Oakland cDepartments of Obstetrics and Gynecology and Microbiology, Immunology and Molecular Genetics, David Geffen School of Medicine at University of California Los Angeles dDepartment of Epidemiology, UCLA Fielding School of Public Health, Los Angeles eDepartment of Pathology and Laboratory Medicine, David Geffen School of Medicine, University of California, Los Angeles fDepartment of Medicine and San Francisco General Hospital, University of California, San Francisco, San Francisco gLos Angeles Medical Center, Kaiser Permanente Southern California, Los Angeles, California, USA.
Lanfang Xu
Michael J Silverberg
Otoniel Martínez-Maza
Lie-Hong Chen
Brandon Castor
Donald I Abrams
Hongbin D Zha
Reina Haque
Jonathan Said
Kaiser Permanente · USUniversity of California, Los Angeles · USLos Angeles Medical Center · USSan Francisco General Hospital · US

Funding

NATIONAL NEUROLOGICAL AIDS BANKU24MH100929 · NIMH · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI SINGER, ELYSE J · 2013 to 2023
$12.5M
National Neurological AIDS BankU01MH083500 · NIMH · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI SINGER, ELYSE J · 2008 to 2012
$7.2M
Prognostic Markers for HIV-Postive Diffuse Large B-Cell LymphomaR01CA134234 · NCI · KAISER FOUNDATION RESEARCH INSTITUTE · PI CHAO, CHUN R. · 2008 to 2011
$1.7M
NCI NIH HHS R01 CA134234NCI NIH HHS R01CA134234-01NIMH NIH HHS U01 MH083500NIMH NIH HHS U24 MH100929
6 · The paper itself

Abstract

objectiveUnderstanding tumor microenvironment and its impact on prognosis of HIV-related lymphomas may provide insight into novel therapeutic strategies.

designWe characterized the relationship between infiltrating immune cells with tumor characteristics, HIV disease history and survival in 80 patients with HIV-related diffuse large B-cell lymphoma (DLBCL) diagnosed in the era of combined antiretroviral therapy (1996-2007) at Kaiser Permanente California. Eighty patients with HIV-unrelated DLBCL were included for comparison.

methodsData on patients' clinical history were obtained from Kaiser Permanente's electronic health records. The density of stromal CD4, CD8 and FOXP3 T cells and CD68 macrophages, as well as tumor molecular characteristics were examined using immunohistochemistry. The associations between stromal immune infiltration and patient's clinical history or tumor characteristics were examined using Kruskal-Wallis tests or Pearson's correlation coefficient. The effect of stromal immune infiltration on 2-year mortality was evaluated in multivariable logistic regression.

resultsCompared with HIV-unrelated DLBCL, patients with HIV-related DLBCL had significantly reduced stromal CD4 and FOXP3 T cells, but increased density of macrophages. Increased density of stromal macrophages was correlated with lower circulating CD4 cell count at DLBCL diagnosis. Tumor molecular characteristics, including BCL6, p53 and cMYC expression, but not Epstein-Barr virus infection status, were significantly correlated with stromal immune infiltration, particularly FOXP3 T cells. A higher density of infiltrating CD8 T cell was significantly associated with reduced mortality in patients with HIV-related DLBCL (odds ratio = 0.30 [0.09-0.97] for ≥25 vs. <10%).

conclusionThese data provide evidence for the prognostic significance of cytotoxic T cells in determining outcomes of HIV-related lymphoma.

Indexed as

AdultAntigens, CDAntigens, Differentiation, MyelomonocyticCaliforniaCD4-Positive T-LymphocytesCD68 MoleculeCD8-Positive T-LymphocytesFemaleForkhead Transcription FactorsHIV InfectionsHumansImmunohistochemistryLymphoma, Large B-Cell, DiffuseMacrophagesMaleMiddle AgedAntigens, CDAntigens, Differentiation, MyelomonocyticCD68 antigen, humanCD68 MoleculeForkhead Transcription FactorsFOXP3 protein, human

Identifiers

PMID26355571
PMCPMC4632648
OpenAlexW2292686491

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.