Evidence map›Paper›PMID 26355090›Full record

ArticleJournal of virology2015

Exclusive Decoration of Simian Immunodeficiency Virus Env with High-Mannose Type N-Glycans Is Not Compatible with Mucosal Transmission in Rhesus Macaques.

Christina B Karsten, Falk F R Buettner, Samanta Cajic, Inga Nehlmeier, Berit Neumann, Antonina Klippert, Ulrike Sauermann, Udo Reichl, Rita Gerardy-Schahn, Erdmann Rapp and 2 more

Open access · bronzeAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of virology, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.6field-weighted citation impact, top 31% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 7 citations in OpenAlex.

  1. Review
  2. Article
  3. Mechanistic understanding ofThe Journal of biological chemistry · 2017
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 3 institutions in 1 country.

Christina B KarstenInstitute for Cellular Chemistry, Hannover Medical School, Hannover, Germany Infection Biology Unit, German Primate Center, Göttingen, Germany.
Falk F R BuettnerInstitute for Cellular Chemistry, Hannover Medical School, Hannover, Germany.
Samanta CajicMax-Planck-Institute for Dynamics of Complex Technical Systems, Magdeburg, Germany.
Inga NehlmeierInfection Biology Unit, German Primate Center, Göttingen, Germany.
Berit NeumannUnit of Infection Models, German Primate Center, Göttingen, Germany.
Antonina KlippertUnit of Infection Models, German Primate Center, Göttingen, Germany.
Ulrike SauermannUnit of Infection Models, German Primate Center, Göttingen, Germany.
Udo ReichlMax-Planck-Institute for Dynamics of Complex Technical Systems, Magdeburg, Germany.
Rita Gerardy-SchahnInstitute for Cellular Chemistry, Hannover Medical School, Hannover, Germany.
Erdmann RappMax-Planck-Institute for Dynamics of Complex Technical Systems, Magdeburg, Germany glyXera GmbH, Magdeburg, Germany.
Christiane Stahl-HennigUnit of Infection Models, German Primate Center, Göttingen, Germany.
Stefan PöhlmannInfection Biology Unit, German Primate Center, Göttingen, Germany spoehlmann@dpz.eu.ORCID http://orcid.org/0000-0001-6086-9136
German Primate Center · DEMax Planck Institute for Dynamics of Complex Technical Systems · DEMedizinische Hochschule Hannover · DE

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Human immunodeficiency virus (HIV) and simian immunodeficiency virus (SIV) envelope (Env) proteins are extensively decorated with N-glycans, predominantly of the high-mannose type. However, it is unclear how high-mannose N-glycans on Env impact viral spread. We show that exclusive modification of SIV Env with these N-glycans reduces viral infectivity and abrogates mucosal transmission, despite increasing viral capture by immune cell lectins. Thus, high-mannose N-glycans have opposed effects on SIV infectivity and lectin reactivity, and a balance might be required for efficient mucosal transmission.

Indexed as

AnimalsCell LineGene Products, envHIV-1HIV InfectionsHumansMacaca mulattaMannoseMucous MembranePolysaccharidesSimian Acquired Immunodeficiency SyndromeSimian Immunodeficiency VirusGene Products, envMannosePolysaccharides

Identifiers

PMID26355090
PMCPMC4645679
OpenAlexW2235836249

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-SA
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.