ArticleScientific reports2015
Structural Heterogeneity of Mitochondria Induced by the Microtubule Cytoskeleton.
Article in Scientific reports, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
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Who cites it
18 citing papers in PubMed, 29 citations in OpenAlex.
- Mitochondrial networks through the lens of mathematics.Physical biology · 2023Review
- MitoTNT: Mitochondrial Temporal Network Tracking for 4D live-cell fluorescence microscopy data.PLoS computational biology · 2023Article
- Alterations in Cytoskeleton and Mitochondria in the Development and Reversal of Steatosis in Human Hepatocytes.Cellular and molecular gastroenterology and hepatology · 2023Article
- Automated analysis of mitochondrial dimensions in mesenchymal stem cells: Current methods and future perspectives.Heliyon · 2023Review
- Universal dynamics of mitochondrial networks: a finite-size scaling analysis.Scientific reports · 2022Article
- Targeting cellular senescence based on interorganelle communication, multilevel proteostasis, and metabolic control.The FEBS journal · 2021Review
- The social nature of mitochondria: Implications for human health.Neuroscience and biobehavioral reviews · 2021Review
- Intracardiac administration of ephrinA1-Fc preserves mitochondrial bioenergetics during acute ischemia/reperfusion injury.Life sciences · 2019Article
- Tracking intra- and inter-organelle signaling of mitochondria.The FEBS journal · 2019Review
- Mitochondrial-cytoskeletal interactions: dynamic associations that facilitate network function and remodeling.Current opinion in physiology · 2018Article
- Mitochondrial network complexity emerges from fission/fusion dynamics.Scientific reports · 2018Article
- Regulation of Mitochondrial Structure and Dynamics by the Cytoskeleton and Mechanical Factors.International journal of molecular sciences · 2017Review
- Deletion of RhoA in Progesterone Receptor-Expressing Cells Leads to Luteal Insufficiency and Infertility in Female Mice.Endocrinology · 2017Article
- Adhesion Regulating Molecule 1 Mediates HAP40 Overexpression-Induced Mitochondrial Defects.International journal of biological sciences · 2017Article
- Role of keratin 24 in human epidermal keratinocytes.PloS one · 2017Article
- Mitochondria, cholesterol and cancer cell metabolism.Clinical and translational medicine · 2016Review
- Long range physical cell-to-cell signalling via mitochondria inside membrane nanotubes: a hypothesis.Theoretical biology & medical modelling · 2016Review
- Altered Cytoskeleton as a Mitochondrial Decay Signature in the Retinal Pigment Epithelium.The protein journal · 2016Article
Corrections and comments
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
By events of fusion and fission mitochondria generate a partially interconnected, irregular network of poorly specified architecture. Here, its organization is examined theoretically by taking into account the physical association of mitochondria with microtubules. Parameters of the cytoskeleton mesh are derived from the mechanics of single fibers. The model of the mitochondrial reticulum is formulated in terms of a dynamic spatial graph. The graph dynamics is modulated by the density of microtubules and their crossings. The model reproduces the full spectrum of experimentally found mitochondrial configurations. In centrosome-organized cells, the chondriome is predicted to develop strong structural inhomogeneity between the cell center and the periphery. An integrated analysis of the cytoskeletal and the mitochondrial components reveals that the structure of the reticulum depends on the balance between anterograde and retrograde motility of mitochondria on microtubules, in addition to fission and fusion. We propose that it is the combination of the two processes that defines synergistically the mitochondrial structure, providing the cell with ample capabilities for its regulative adaptation.
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