ArticleGenome research2015
Linked selection and recombination rate variation drive the evolution of the genomic landscape of differentiation across the speciation continuum of Ficedula flycatchers.
Article in Genome research, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 177 papers.
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177 citing papers in PubMed.
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- Human Impacts on Great Lakes Walleye Sander vitreus Structure, Diversity and Local Adaptation.Molecular ecology · 2025Article
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- Divergent selection, recombination variability, and noncoding introgression drive speciation and adaptation in threadfin Eleutheronema.Communications biology · 2025Article
- Genealogical Analysis of Replicate Flower Colour Hybrid Zones in Antirrhinum.Molecular ecology · 2025Article
- Recombination Rate and Recurrent Linked Selection Shape Correlated Genomic Landscapes Across a Continuum of Divergence in Swallows.Molecular ecology · 2025Article
- Evidence that genetic drift not adaptation drives fast-Z and large-Z effects in Ficedula flycatchers.Molecular ecology · 2025Article
- Article
- Opinion: Why Sex-Based Genomic Differentiation Should Not Be Overlooked in Population Genetics.Molecular ecology · 2025Article
- Exploring evolutionary mechanisms of genomic divergence in marine intertidal limpets.Heredity · 2025Article
- Genetic Isolation among Four Lineages of Silene nutans.Plant & cell physiology · 2025Article
- Reconciling Gene Tree Discordance and Biogeography in European Crows.Molecular ecology · 2025Article
117 more citing papers are in PubMed but not listed here.
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18 authors.
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Abstract
Speciation is a continuous process during which genetic changes gradually accumulate in the genomes of diverging species. Recent studies have documented highly heterogeneous differentiation landscapes, with distinct regions of elevated differentiation ("differentiation islands") widespread across genomes. However, it remains unclear which processes drive the evolution of differentiation islands; how the differentiation landscape evolves as speciation advances; and ultimately, how differentiation islands are related to speciation. Here, we addressed these questions based on population genetic analyses of 200 resequenced genomes from 10 populations of four Ficedula flycatcher sister species. We show that a heterogeneous differentiation landscape starts emerging among populations within species, and differentiation islands evolve recurrently in the very same genomic regions among independent lineages. Contrary to expectations from models that interpret differentiation islands as genomic regions involved in reproductive isolation that are shielded from gene flow, patterns of sequence divergence (d(xy) and relative node depth) do not support a major role of gene flow in the evolution of the differentiation landscape in these species. Instead, as predicted by models of linked selection, genome-wide variation in diversity and differentiation can be explained by variation in recombination rate and the density of targets for selection. We thus conclude that the heterogeneous landscape of differentiation in Ficedula flycatchers evolves mainly as the result of background selection and selective sweeps in genomic regions of low recombination. Our results emphasize the necessity of incorporating linked selection as a null model to identify genome regions involved in adaptation and speciation.
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