ArticleThe Journal of neuroscience : the official journal of the Society for Neuroscience2015
Infralimbic EphB2 Modulates Fear Extinction in Adolescent Rats.
Article in The Journal of neuroscience : the official journal of the Society for Neuroscience, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
What it found
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Who cites it
10 citing papers in PubMed, 18 citations in OpenAlex.
- Purinergic P2X7 receptor-mediated inflammation precedes PTSD-related behaviors in rats.Brain, behavior, and immunity · 2023Article
- Sex-dependent effects of microglial reduction on impaired fear extinction induced by single prolonged stress.Frontiers in behavioral neuroscience · 2022Article
- Predation threats for a 24-h period activated the extension of axons in the brains of Xenopus tadpoles.Scientific reports · 2020Article
- Future considerations for pediatric cancer survivorship: Translational perspectives from developmental neuroscience.Developmental cognitive neuroscience · 2019Review
- Neurocognitive Development of Motivated Behavior: Dynamic Changes across Childhood and Adolescence.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2018Review
- Activation of EphB2 Forward Signaling Enhances Memory Consolidation.Cell reports · 2018Article
- Fear extinction requires infralimbic cortex projections to the basolateral amygdala.Translational psychiatry · 2018Article
- Emotional learning, stress, and development: An ever-changing landscape shaped by early-life experience.Neurobiology of learning and memory · 2017Review
- Amygdala EphB2 Signaling Regulates Glutamatergic Neuron Maturation and Innate Fear.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2016Article
- EphB2 in the Medial Prefrontal Cortex Regulates Vulnerability to Stress.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2016Article
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Authors and funding
6 authors at 2 institutions in 1 country.
Funding
Abstract
Adolescent rats are prone to impaired fear extinction, suggesting that mechanistic differences in extinction could exist in adolescent and adult rats. Since the infralimbic cortex (IL) is critical for fear extinction, we used PCR array technology to identify gene expression changes in IL induced by fear extinction in adolescent rats. Interestingly, the ephrin type B receptor 2 (EphB2), a tyrosine kinase receptor associated with synaptic development, was downregulated in IL after fear extinction. Consistent with the PCR array results, EphB2 levels of mRNA and protein were reduced in IL after fear extinction compared with fear conditioning, suggesting that EphB2 signaling in IL regulates fear extinction memory in adolescents. Finally, reducing EphB2 synthesis in IL with shRNA accelerated fear extinction learning in adolescent rats, but not in adult rats. These findings identify EphB2 in IL as a key regulator of fear extinction during adolescence, perhaps due to the increase in synaptic remodeling occurring during this developmental phase.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.