Evidence map›Paper›PMID 26354897›Full record

SynthesisCancer causes & control : CCC2015

A systematic review of dietary, nutritional, and physical activity interventions for the prevention of prostate cancer progression and mortality.

Lucy E Hackshaw-McGeagh, Rachel E Perry, Verity A Leach, Sara Qandil, Mona Jeffreys, Richard M Martin, J Athene Lane

Open access · hybridAbstract readSystematic Review
PubMed Full text at PMC Publisher
In one paragraph

Synthesis in Cancer causes & control : CCC, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 37 papers, 6 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
37citing papers in PubMed, 6 pooled it
10.7field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

37 citing papers in PubMed, 6 syntheses or guidelines pooled it, 92 citations in OpenAlex.

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  4. A Systematic Review of Exercise Systematic Reviews in the Cancer Literature (2005-2017).PM & R : the journal of injury, function, and rehabilitation · 2017
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  14. What works to engage cancer patients with fatigue in exercise: a scoping review of RCT-based interventions.Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer · 2026
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4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

7 authors at 2 institutions in 1 country.

Lucy E Hackshaw-McGeaghNational Institute for Health Research (NIHR) Bristol Nutritional Biomedical Research Unit, University Hospitals Bristol NHS Foundation Trust and the University of Bristol, Bristol, BS2 8AE, UK. lucy.hackshaw@bristol.ac.uk.
Rachel E PerryNational Institute for Health Research (NIHR) Bristol Nutritional Biomedical Research Unit, University Hospitals Bristol NHS Foundation Trust and the University of Bristol, Bristol, BS2 8AE, UK.
Verity A LeachSchool of Social and Community Medicine, University of Bristol, Bristol, BS8 2PS, UK.
Sara QandilSchool of Social and Community Medicine, University of Bristol, Bristol, BS8 2PS, UK.
Mona JeffreysSchool of Social and Community Medicine, University of Bristol, Bristol, BS8 2PS, UK.
Richard M MartinNational Institute for Health Research (NIHR) Bristol Nutritional Biomedical Research Unit, University Hospitals Bristol NHS Foundation Trust and the University of Bristol, Bristol, BS2 8AE, UK.
J Athene LaneNational Institute for Health Research (NIHR) Bristol Nutritional Biomedical Research Unit, University Hospitals Bristol NHS Foundation Trust and the University of Bristol, Bristol, BS2 8AE, UK.
University of Bristol · GBUniversity Hospitals Bristol NHS Foundation Trust · GB

Funding

Cancer Research UK 19169Cancer Research UK A19169Cancer Research UK C18281/A19169
6 · The paper itself

Abstract

purposeGiven the long-term, although potentially fatal, nature of prostate cancer, there is increasing observational evidence for the reduction in disease progression and mortality through changes in lifestyle factors.

methodsWe systematically reviewed dietary, nutritional, and physical activity randomized interventions aimed at modifying prostate cancer progression and disease-specific mortality, including a detailed assessment of risk of bias and methodological quality.

resultsForty-four randomized controlled trials of lifestyle interventions, with prostate cancer progression or mortality outcomes, were identified. Substantial heterogeneity of the data prevented a meta-analysis. The included trials involved 3,418 prostate cancer patients, median 64 men per trial, from 13 countries. A trial of a nutritional supplement of pomegranate seed, green tea, broccoli, and turmeric; a trial comparing flaxseed, low-fat diet, flaxseed, and low-fat diet versus usual diet; and a trial supplementing soy, lycopene, selenium, and coenzyme Q10, all demonstrated beneficial effects. These trials were also assessed as having low risk of bias and high methodological quality (as were seven other trials with no evidence of benefit). The remaining trials were either underpowered, at high or unclear risk of bias, inadequately reported, of short duration or measured surrogate outcomes of unproven relationship to mortality or disease progression, which precluded any benefits reported being reliable.

conclusionLarge, well-designed randomized trials with clinical endpoints are recommended for lifestyle modification interventions.

Indexed as

DietDietary SupplementsLife StyleAgedDisease ProgressionHumansMaleMiddle AgedMotor ActivityProstatic NeoplasmsDietNutritionPhysical activityProstate cancerRandomized controlled trialsSystematic review

Identifiers

PMID26354897
PMCPMC4596907
OpenAlexW2106148864

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.