ArticleNucleic acids research2015
A legion of potential regulatory sRNAs exists beyond the typical microRNAs microcosm.
Article in Nucleic acids research, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
12 citing papers in PubMed, 17 citations in OpenAlex.
- MirGeneDB 3.0: improved taxonomic sampling, uniform nomenclature of novel conserved microRNA families and updated covariance models.Nucleic acids research · 2025Article
- Accurate microRNA annotation of animal genomes using trained covariance models of curated microRNA complements in MirMachine.Cell genomics · 2023Article
- The limits of human microRNA annotation have been met.RNA (New York, N.Y.) · 2022Article
- MirGeneDB 2.0: the metazoan microRNA complement.Nucleic acids research · 2020Article
- Improving Bioinformatics Prediction of microRNA Targets by Ranks Aggregation.Frontiers in genetics · 2019Article
- miRCarta: a central repository for collecting miRNA candidates.Nucleic acids research · 2018Article
- Article
- Web-based NGS data analysis using miRMaster: a large-scale meta-analysis of human miRNAs.Nucleic acids research · 2017Article
- Short intron-derived ncRNAs.Nucleic acids research · 2017Article
- Coordinated Actions of MicroRNAs with other Epigenetic Factors Regulate Skeletal Muscle Development and Adaptation.International journal of molecular sciences · 2017Review
- Natural Antisense Transcripts at the Interface between Host Genome and Mobile Genetic Elements.Frontiers in microbiology · 2017Article
- Posttranscriptional Regulation Controls Calretinin Expression in Malignant Pleural Mesothelioma.Frontiers in genetics · 2017Article
Corrections and comments
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Authors and funding
4 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Post ENCODE, regulatory sRNAs (rsRNAs) like miRNAs have established their status as one of the core regulatory elements of cell systems. However, large number of rsRNAs are compromised due to traditional approaches to identify miRNAs, limiting the otherwise vast world of rsRNAs mainly to hair-pin loop bred typical miRNAs. The present study has analyzed for the first time a huge volume of sequencing data from 4997 individuals and 25 cancer types to report 11 234 potentially regulatory small RNAs which appear to have deep reaching impact. The rsRNA-target interactions have been studied and validated extensively using experimental data from AGO-crosslinking, DGCR8 knockdown, CLASH, proteome and expression data. A subset of such interactions was also validated independently in the present study using multiple cell lines, by qPCR. Several of the potential rsRNAs have emerged as a critical cancer biomarker controlling some important spots of cell system. The entire study has been presented into an interactive info-analysis portal handling more than 260 GB of processed data. The possible degree of cell system regulation by sRNAs appears to be much higher than previously assumed.
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Registered trials
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