Evidence map›Paper›PMID 26354764›Full record

ArticleOphthalmology2015

Joint Associations of Diet, Lifestyle, and Genes with Age-Related Macular Degeneration.

Kristin J Meyers, Zhe Liu, Amy E Millen, Sudha K Iyengar, Barbara A Blodi, Elizabeth Johnson, D Max Snodderly, Michael L Klein, Karen M Gehrs, Lesley Tinker and 4 more

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Ophthalmology, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 34 papers.

0numbers the graph read from it
0cells of the map it votes in
34citing papers in PubMed
6.8field-weighted citation impact, top 3% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

34 citing papers in PubMed, 61 citations in OpenAlex.

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  10. Immunogenetic and Environmental Factors in Age-Related Macular Disease.International journal of molecular sciences · 2024
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors at 10 institutions in 1 country.

Kristin J MeyersDepartment of Ophthalmology and Visual Sciences, McPherson Eye Research Institute, University of Wisconsin School of Medicine and Public Health, Madison, Wisconsin.
Zhe LiuDepartment of Ophthalmology and Visual Sciences, McPherson Eye Research Institute, University of Wisconsin School of Medicine and Public Health, Madison, Wisconsin.
Amy E MillenDepartment of Epidemiology and Environmental Health, School of Public Health and Health Professions, University at Buffalo, The State University of New York, Buffalo, New York.
Sudha K IyengarDepartment of Epidemiology and Biostatistics, Case Western Reserve University, Cleveland, Ohio.
Barbara A BlodiDepartment of Ophthalmology and Visual Sciences, McPherson Eye Research Institute, University of Wisconsin School of Medicine and Public Health, Madison, Wisconsin.
Elizabeth JohnsonJean Mayer USDA Human Nutrition, Research Center on Aging, Tufts University, Boston, Massachusetts.
D Max SnodderlyDepartment of Neuroscience, University of Texas, Austin, Texas.
Michael L KleinCasey Eye Institute, Department of Ophthalmology, Oregon Health & Science University, Portland, Oregon.
Karen M GehrsDepartment of Ophthalmology & Visual Sciences, University of Iowa Hospital & Clinics, Iowa City, Iowa.
Lesley TinkerDepartment of Cancer Prevention Research Program, Fred Hutchinson Cancer Research Center, Seattle, Washington.
Gloria E SartoDepartment of Obstetrics & Gynecology, School of Medicine & Public Health, University of Wisconsin, Madison, Wisconsin.
Jennifer RobinsonDepartment of Epidemiology, University of Iowa College of Public Health, Iowa City, Iowa.
Robert B WallaceDepartment of Epidemiology, University of Iowa College of Public Health, Iowa City, Iowa.
Julie A MaresDepartment of Ophthalmology and Visual Sciences, McPherson Eye Research Institute, University of Wisconsin School of Medicine and Public Health, Madison, Wisconsin. Electronic address: jmarespe@wisc.edu.
Smith-Kettlewell Eye Research Institute · USUniversity of Iowa · USCase Western Reserve University · USFred Hutch Cancer Center · USJean Mayer Human Nutrition Research Center on Aging · USOregon Health & Science University · USThe University of Texas at Austin · USUniversity at Buffalo, State University of New York · USUniversity of Iowa Hospitals and Clinics · USUniversity of Wisconsin–Madison · US

Funding

Translational Bioimaging Core Shared ResourceP30CA015704 · NCI · FRED HUTCHINSON CANCER RESEARCH CENTER · PI Marian Esvelt · 1985 to 2026
$296.4M
TRAINING IN NUTRITIONT32DK007665 · NIDDK · UNIVERSITY OF WISCONSIN-MADISON · PI GUY E GROBLEWSKI, Chi- Liang Eric Yen · 1993 to 2026
$9.2M
CAROTENOIDS &AGE-RELATED EYE DISEASE IN WOMEN'S HEALTHU10EY013018 · NEI · UNIVERSITY OF WISCONSIN MADISON · PI MARES, JULIE A · 2000 to 2004
$4.4M
Diet and Lifestyle Factors Reducing Risk for Age-Related Eye DiseaseR01EY016886 · NEI · UNIVERSITY OF WISCONSIN-MADISON · PI IYENGAR, SUDHA K, MARES, JULIE A · 2007 to 2013
$2.7M
NCI NIH HHS P30 CA015704NEI NIH HHS EY013018NEI NIH HHS EY016886NEI NIH HHS R01 EY016886NEI NIH HHS U10 EY013018NHLBI NIH HHS HHSN268201100001INHLBI NIH HHS HHSN268201100002INHLBI NIH HHS HHSN268201100003INHLBI NIH HHS HHSN268201100004INHLBI NIH HHS HHSN268201100046CNIA NIH HHS HHSN271201100004CNIDDK NIH HHS T32 DK007665WHI NIH HHS HHSN268201100001CWHI NIH HHS HHSN268201100002CWHI NIH HHS HHSN268201100003CWHI NIH HHS HHSN268201100004C
6 · The paper itself

Abstract

purposeUnhealthy lifestyles have been associated with increased odds for age-related macular degeneration (AMD). Whether this association is modified by genetic risk for AMD is unknown and was investigated.

designInteractions between healthy lifestyles AMD risk genotypes were studied in relation to the prevalence of AMD, assessed 6 years later.

participantsWomen 50 to 79 years of age in the Carotenoids in Age-Related Eye Disease Study with exposure and AMD data (n=1663).

methodsHealthy lifestyle scores (0-6 points) were assigned based on Healthy Eating Index scores, physical activity (metabolic equivalent of task hours/week), and smoking pack years assessed in 1994 and 1998. Genetic risk was based on Y402H in complement factor H (CFH) and A69S in age-related maculopathy susceptibility locus 2 (ARMS2). Additive and multiplicative interactions in odds ratios were assessed using the synergy index and a multiplicative interaction term, respectively.

main outcome measuresAMD presence and severity were assessed from grading of stereoscopic fundus photographs taken in 2001-2004. AMD was present in 337 women, 91% of whom had early AMD.

resultsThe odds of AMD were 3.3 times greater (95% confidence interval [CI], 1.8-6.1) in women with both low healthy lifestyle score (0-2) and high-risk CFH genotype (CC), relative to those who had low genetic risk (TT) and high healthy lifestyle scores (4-6). There were no significant additive (synergy index [SI], 1.08; 95% CI, 0.70-1.67) or multiplicative (Pinteraction=0.94) interactions in the full sample. However, when limiting the sample to women with stable diets before AMD assessment (n=728) the odds for AMD associated with low healthy lifestyle scores and high-risk CFH genotype were strengthened (odds ratio, 4.6; 95% CI, 1.8-11.6) and the synergy index was significant (SI, 1.34; 95% CI, 1.05-1.70). Adjusting for dietary lutein and zeaxanthin attenuated, and therefore partially explained, the joint association. There were no significant additive or multiplicative interactions for ARMS2 and lifestyle score.

conclusionsHaving unhealthy lifestyles and 2 CFH risk alleles increased AMD risk (primarily in the early stages), in an or additive or greater (synergistic) manner. However, unhealthy lifestyles increased AMD risk regardless of AMD risk genotype.

Indexed as

DietLife StylePolymorphism, Single NucleotideAgedAllelesComplement Factor HFeeding BehaviorFemaleGenotyping TechniquesHealth Status IndicatorsHumansLuteinMacular DegenerationMiddle AgedOdds RatioPrevalenceARMS2 protein, humanCFH protein, humanComplement Factor HLuteinProteinsZeaxanthins

Identifiers

PMID26354764
PMCPMC4714866
OpenAlexW2150098643

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.