Evidence map›Paper›PMID 26354540›Full record

Trial reportThe American journal of clinical nutrition2015

Type and amount of dietary protein in the treatment of metabolic syndrome: a randomized controlled trial.

Alison M Hill, Kristina A Harris Jackson, Michael A Roussell, Sheila G West, Penny M Kris-Etherton

2 registry-linked trialsOpen access · bronzeAbstract readComparative StudyRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in The American journal of clinical nutrition, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 2 registered trials, which are not on this map. Cited by 41 papers, 8 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
41citing papers in PubMed, 8 pooled it
6.3field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT00937638 nacompletednot on this map

BOLD (Beef in an Optimal Lean Diet) Effects on Established and Emerging Cardiovascular Disease (CVD) Risk Factors: Effects on Metabolic Syndrome (BOLD-X)

TypeinterventionalSponsorPenn State UniversityRan2009 to 2012Enrolled63ConditionsMetabolic Syndrome, Cardiovascular DiseaseArmsBOLD Diet, BOLD-X Diet, Modified DASH Diet
NCT04025073 nacompletednot on this mapstarted 2017, after this paper: background citation

The Impact of Dietary Habits and Nutrition Intervention on Metabolic Syndrome Parameters in Hospitalized Individuals With the Diagnosis of Schizophrenia

TypeinterventionalSponsorTamara SorićRan2017 to 2017Enrolled79ConditionsMetabolic SyndromeArmsDietary Approaches to Stop Hypertension, Nutrition education program
3 · Its place in the literature

Who cites it

41 citing papers in PubMed, 8 syntheses or guidelines pooled it, 74 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
  3. Pooled it
  4. Pooled it
  5. Pooled it
  6. Pooled it
  7. Pooled it
  8. Pooled it
  9. Trial
  10. Trial
  11. Trial
  12. Trial
  13. Trial
  14. Trial
  15. Trial
  16. Trial
  17. Trial
  18. Trial
  19. Trial
  20. Trial
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 3 institutions in 3 countries.

Alison M HillSchool of Pharmacy & Medical Sciences, University of South Australia, Adelaide, Australia; and Department of Nutritional Sciences and.ORCID http://orcid.org/0000-0002-6732-4224
Kristina A Harris JacksonDepartment of Nutritional Sciences and.
Michael A RoussellDepartment of Nutritional Sciences and.
Sheila G WestDepartment of Nutritional Sciences and Department of Biobehavioral Health, The Pennsylvania State University, University Park, PA.
Penny M Kris-EthertonDepartment of Nutritional Sciences and pmk3@psu.edu.
Park University · USPennsylvania State University · USUniversity of South Australia · AU

Funding

WRITING AND THE DAILY EXPERIENCE OF ILLNESSM01RR010732 · NCRR · PENNSYLVANIA STATE UNIV HERSHEY MED CTR · PI LOHSE, BARBARA · 1995 to 2009
$29.8M
NCRR NIH HHS M01RR10732
6 · The paper itself

Abstract

backgroundFood-based dietary patterns emphasizing plant protein that were evaluated in the Dietary Approaches to Stop Hypertension (DASH) and OmniHeart trials are recommended for the treatment of metabolic syndrome (MetS). However, the contribution of plant protein to total protein in these diets is proportionally less than that of animal protein.

objectiveThis study compared 3 diets varying in type (animal compared with plant) and amount of protein on MetS criteria.

designSixty-two overweight adults with MetS consumed a healthy American diet for 2 wk before being randomly allocated to either a modified DASH diet rich in plant protein (18% protein, two-thirds plant sources, n = 9 males, 12 females), a modified DASH diet rich in animal protein (Beef in an Optimal Lean Diet: 18.4% protein, two-thirds animal sources, n = 9 males, 11 females), or a moderate-protein diet (Beef in an Optimal Lean Diet Plus Protein: 27% protein, two-thirds animal sources, n = 10 males, 11 females). Diets were compared across 3 phases of energy balance: 5 wk of controlled (all foods provided) weight maintenance (WM), 6 wk of controlled weight loss (minimum 500-kcal/d deficit) including exercise (WL), and 12 wk of prescribed, free-living weight loss (FL). The primary endpoint was change in MetS criteria.

resultsAll groups achieved ∼5% weight loss at the end of the WL phase and maintained it through FL, with no between-diet differences (WM compared with WL, FL, P < 0.0001; between diets, P = NS). All MetS criteria decreased independent of diet composition (main effect of phase, P < 0.01; between diets, P = NS). After WM, all groups had a MetS prevalence of 80-90% [healthy American diet (HAD) compared with WM, P = NS], which decreased to 50-60% after WL and was maintained through FL (HAD, WM vs WL, FL, P < 0.01).

conclusionsWeight loss was the primary modifier of MetS resolution in our study population regardless of protein source or amount. Our findings demonstrate that heart-healthy weight-loss dietary patterns that emphasize either animal or plant protein improve MetS criteria similarly. This study was registered at clinicaltrials.gov as NCT00937638.

Indexed as

DietFeeding BehaviorAbsorptiometry, PhotonAdultAnimalsBody CompositionBody WeightCattleCholesterol, HDLCholesterol, LDLDietary ProteinsEndpoint DeterminationExerciseFemaleHumansLogistic ModelsCholesterol, HDLCholesterol, LDLDietary ProteinsMilk ProteinsTriglyceridesbody compositiondietary proteinlean beefmetabolic syndromeweight loss

Identifiers

PMID26354540
PMCPMC4588738
OpenAlexW2142860076

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.