Evidence map›Paper›PMID 26354537›Full record

Observational studyThe American journal of clinical nutrition2015

Carotenoids, vitamin A, vitamin C, vitamin E, and folate and risk of self-reported hearing loss in women.

Sharon G Curhan, Konstantina M Stankovic, Roland D Eavey, Molin Wang, Meir J Stampfer, Gary C Curhan

Open access · bronzeAbstract readObservational Study
PubMed Full text at PMC Publisher
In one paragraph

Observational study in The American journal of clinical nutrition, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 34 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
34citing papers in PubMed, 2 pooled it
2.6field-weighted citation impact, top 11% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

34 citing papers in PubMed, 2 syntheses or guidelines pooled it, 63 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
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  6. Article
  7. Role of Oxidative Stress in Sensorineural Hearing Loss.International journal of molecular sciences · 2024
    Review
  8. Article
  9. Article
  10. Diabetes mellitus and hearing loss.Molecular medicine (Cambridge, Mass.) · 2023
    Review
  11. Article
  12. Article
  13. Review
  14. Review
  15. Article
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4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

6 authors at 3 institutions in 1 country.

Sharon G CurhanChanning Division of Network Medicine and Harvard Medical School, Boston MA scurhan@partners.org.
Konstantina M StankovicEaton-Peabody Laboratories and Department of Otolaryngology, Massachusetts Eye and Ear Infirmary, Boston, MA; Department of Otology and Laryngology, Harvard Medical School, Boston, MA; Program in Speech and Hearing Bioscience and Technology, Division of Health Science and Technology, Harvard and Massachusetts Institute of Technology, Boston, MA;
Roland D EaveyVanderbilt Bill Wilkerson Center for Otolaryngology and Communication Sciences, Vanderbilt University School of Medicine, Nashville, TN; and.
Molin WangChanning Division of Network Medicine and Departments of Biostatistics and Epidemiology, Harvard School of Public Health, Boston, MA.
Meir J StampferChanning Division of Network Medicine and Epidemiology, Harvard School of Public Health, Boston, MA.
Gary C CurhanChanning Division of Network Medicine and Renal Division, Department of Medicine, Brigham and Women's Hospital, Boston, MA; Epidemiology, Harvard School of Public Health, Boston, MA, Harvard Medical School, Boston MA.
Brigham and Women's Hospital · USMassachusetts Eye and Ear Infirmary · USVanderbilt University · US

Funding

Life Course Cancer Epidemiology Cohort in WomenUM1CA176726 · NCI · HARVARD SCHOOL OF PUBLIC HEALTH · PI WILLETT, WALTER C. · 2013 to 2017
$15.7M
Risk Factors for Hearing LossU01DC010811 · NIDCD · BRIGHAM AND WOMEN'S HOSPITAL · PI CURHAN, GARY C. · 2011 to 2018
$4.0M
NCI NIH HHS UM1 CA176726NIDCD NIH HHS DC010811
6 · The paper itself

Abstract

backgroundHigher intake of certain vitamins may protect against cochlear damage from vascular compromise and oxidative stress, thereby reducing risk of acquired hearing loss, but data are limited.

objectiveWe prospectively examined the relation between carotenoids, vitamin A, vitamin C, vitamin E, and folate intake and risk of self-reported hearing loss in women.

designThis prospective cohort study followed 65,521 women in the Nurses' Health Study II from 1991 to 2009. Baseline and updated information obtained from validated biennial questionnaires was used in Cox proportional hazards regression models to examine independent associations between nutrient intake and self-reported hearing loss.

resultsAfter 1,084,598 person-years of follow-up, 12,789 cases of incident hearing loss were reported. After multivariable adjustment, we observed modest but statistically significant inverse associations between higher intake of β-carotene and β-cryptoxanthin and risk of hearing loss. In comparison with women in the lowest quintile of intake, the multivariable-adjusted RR of hearing loss among women in the highest quintile was 0.88 (95% CI: 0.81, 0.94; P-trend < 0.001) for β-carotene and 0.90 (95% CI: 0.84, 0.96; P-trend < 0.001) for β-cryptoxanthin. In comparison with women with folate intake 200-399 μg/d, very low folate intake (<200 μg/d) was associated with higher risk (RR: 1.19; 95% CI: 1.01, 1.41), and higher intake tended to be associated with lower risk (P-trend = 0.04). No significant associations were observed for intakes of other carotenoids or vitamin A. Higher vitamin C intake was associated with higher risk; in comparison with women with intake <75 mg/d, the RR among women with vitamin C intake ≥1000 mg/d (mainly supplemental) was 1.22 (95% CI: 1.06, 1.42; P-trend = 0.02). There was no significant trend between intake of vitamin E intake and risk.

conclusionHigher intakes of β-carotene, β-cryptoxanthin, and folate, whether total or from diet, are associated with lower risk of hearing loss, whereas higher vitamin C intake is associated with higher risk.

Indexed as

AdultAscorbic Acidbeta CaroteneCohort StudiesCryptoxanthinsDietDietary SupplementsFemaleFolic AcidFollow-Up StudiesFood, FortifiedHearing LossHumansNursesProportional Hazards ModelsProspective StudiesAscorbic Acidbeta CaroteneCryptoxanthinsFolic AcidVitamin AVitamin Eagingcarotenoidsepidemiologyhearing lossvitamins

Identifiers

PMID26354537
PMCPMC4625586
OpenAlexW2114460348

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.