Evidence map›Paper›PMID 26354491›Full record

ArticleEndocrinology and metabolism (Seoul, Korea)2015

Association of the Preoperative Neutrophil-to-ymphocyte Count Ratio and Platelet-to-Lymphocyte Count Ratio with Clinicopathological Characteristics in Patients with Papillary Thyroid Cancer.

Sang Mi Kim, Eun Heui Kim, Bo Hyun Kim, Jong Ho Kim, Su Bin Park, Yoon Jeong Nam, Kang Hee Ahn, Min Young Oh, Won Jin Kim, Yun Kyung Jeon and 3 more

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Article in Endocrinology and metabolism (Seoul, Korea), 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 41 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
41citing papers in PubMed, 2 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

41 citing papers in PubMed, 2 syntheses or guidelines pooled it.

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  20. Serum Inflammation-based Scores in Endocrine Tumors.The Journal of clinical endocrinology and metabolism · 2021
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Sang Mi KimDepartment of Internal Medicine, Dongeui Medical Center, Busan, Korea.
Eun Heui KimDepartment of Internal Medicine, Pusan National University School of Medicine, Busan, Korea.
Bo Hyun KimDepartment of Internal Medicine, Pusan National University School of Medicine, Busan, Korea.
Jong Ho KimDepartment of Internal Medicine, Pusan National University School of Medicine, Busan, Korea.
Su Bin ParkDepartment of Internal Medicine, Pusan National University School of Medicine, Busan, Korea.
Yoon Jeong NamDepartment of Internal Medicine, Pusan National University School of Medicine, Busan, Korea.
Kang Hee AhnDepartment of Internal Medicine, Pusan National University School of Medicine, Busan, Korea.
Min Young OhDepartment of Internal Medicine, Dongeui Medical Center, Busan, Korea.
Won Jin KimDepartment of Internal Medicine, Pusan National University School of Medicine, Busan, Korea.
Yun Kyung JeonDepartment of Internal Medicine, Pusan National University School of Medicine, Busan, Korea.
Sang Soo KimDepartment of Internal Medicine, Pusan National University School of Medicine, Busan, Korea.
Yong Ki KimKim Yong Ki Internal Medicine Clinic, Busan, Korea.
In Ju KimDepartment of Internal Medicine, Pusan National University School of Medicine, Busan, Korea.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundSeveral inflammatory biomarkers, especially a high preoperative neutrophil-to-lymphocyte count ratio (NLR) and platelet-to-lymphocyte count ratio (PLR), are known to be indicator of poor prognosis in several cancers. However, very few studies have evaluated the significance of the NLR and PLR in papillary thyroid cancer (PTC). We evaluated the association of the preoperative NLR and PLR with clinicopathological characteristics in patients with PTC.

methodsThis study included 1,066 female patients who underwent total thyroidectomy for PTC. Patients were stratified into 4 quartiles by preoperative NLR and PLR. And the combination of preoperative NLR and PLR was calculated on the basis of data obtained value of tertile as follows: patients with both an elevated PLR and an elevated NLR were allocated a score of 2, and patients showing one or neither were allocated a score of 1 or 0, respectively.

resultsThe preoperative NLR and PLR were significantly lower in patients aged ≥45 years and in patients with Hashimoto's thyroiditis. The PLR was significantly higher in patients with tumor size >1 cm (P=0.021).When the patients were categorized into the aforementioned four groups, the group with the higher preoperative PLR was found to have a significantly increased incidence of lateral lymph node metastasis (LNM) (P=0.018). However, there are no significant association between the combination of preoperative NLR and PLR and prognostic factors in PTC patients.

conclusionThese results suggest that a preoperative high PLR were significant associated with lateral LNM in female patients with PTC.

Indexed as

Neutrophil-to-lymphocyte ratioPlatelet-to-lymphocyte ratioPrognosisThyroid neoplasms

Identifiers

PMID26354491
PMCPMC4722404

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.