Evidence map›Paper›PMID 26354490›Full record

ArticleEndocrinology and metabolism (Seoul, Korea)2015

Subclinical Atherosclerosis in Patients with Cushing Syndrome: Evaluation with Carotid Intima-Media Thickness and Ankle-Brachial Index.

Luigi Petramala, D'Elia Lorenzo, Gino Iannucci, Antonio Concistré, Laura Zinnamosca, Cristiano Marinelli, Giuseppe De Vincentis, Antonio Ciardi, Giorgio De Toma, Claudio Letizia

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Article in Endocrinology and metabolism (Seoul, Korea), 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
0.5field-weighted citation impact, top 31% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 11 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 1 institution in 1 country.

Luigi PetramalaDepartment of Internal Medicine and Medical Specialties, University of Rome "Sapienza", Rome, Italy.
D'Elia LorenzoDepartment of Internal Medicine and Medical Specialties, University of Rome "Sapienza", Rome, Italy.
Gino IannucciDepartment of Internal Medicine and Medical Specialties, University of Rome "Sapienza", Rome, Italy.
Antonio ConcistréDepartment of Internal Medicine and Medical Specialties, University of Rome "Sapienza", Rome, Italy.
Laura ZinnamoscaDepartment of Internal Medicine and Medical Specialties, University of Rome "Sapienza", Rome, Italy.
Cristiano MarinelliDepartment of Internal Medicine and Medical Specialties, University of Rome "Sapienza", Rome, Italy.
Giuseppe De VincentisSection Nuclear Medicine, Department of Radiology, University of Rome "Sapienza", Rome, Italy.
Antonio CiardiDepartment of Surgery, "P. Valdoni", University of Rome "Sapienza", Rome, Italy.
Giorgio De TomaDepartment of Surgery, "P. Valdoni", University of Rome "Sapienza", Rome, Italy.
Claudio LetiziaDepartment of Internal Medicine and Medical Specialties, University of Rome "Sapienza", Rome, Italy. claudio.letizia@uniroma1.it.
Sapienza University of Rome · IT

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundCushing syndrome (CS) has been described as a killing disease due its cardiovascular complications. In fact, chronic cortisol excess leads to a constellation of complications, including hypertension, hyperglycemia, adiposity, and thromboembolism. The main vascular alteration associated with CS is atherosclerosis.

methodsAim of this study was to analyze carotid intima-media thickness (cIMT) and ankle-brachial index (ABI), two surrogate markers of subclinical atherosclerosis in a consecutive series of CS patients, compared to patients with essential hypertension (EH) and health subjects (HS).

resultsPatients with CS showed a significant increase (P<0.05) of cIMT (0.89±0.17 mm) compared to EH (0.81±0.16 mm) and HS (0.75±0.4 mm), with a high prevalence of plaque (23%; P<0.03). Moreover, CS patients showed a mean ABI values (1.07±0.02) significantly lower respect to HS (1.12±0.11; P<0.05), and a higher percentage (20%) of pathological values of ABI (≤0.9; P<0.03).

conclusionIn conclusion, we confirmed and extended the data of cIMT in CS, and showed that the ABI represent another surrogate marker of subclinical atherosclerosis in this disease.

Indexed as

Ankle brachial indexCarotid intima-media thicknessCushing syndromeSubclinical atherosclerosis

Identifiers

PMID26354490
PMCPMC4722403
OpenAlexW1958759491

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.