ArticleBioEssays : news and reviews in molecular, cellular and developmental biology2015
How rods respond to single photons: Key adaptations of a G-protein cascade that enable vision at the physical limit of perception.
Article in BioEssays : news and reviews in molecular, cellular and developmental biology, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
21 citing papers in PubMed.
- Selective knockout of murine glutamic acid-rich protein 2 significantly alters dark continuous noise in rod photoreceptors.The Journal of physiology · 2026Article
- Tbx genes influence early gene expression and photoreceptor patterning in the chick retina.bioRxiv : the preprint server for biology · 2025Article
- Advantages of human opsins in optogenetic visual restoration.Frontiers in neuroscience · 2025Review
- Molecular Components of Vesicle Cycling at the Rod Photoreceptor Ribbon Synapse.Advances in experimental medicine and biology · 2025Review
- Article
- Layers of inhibitory networks shape receptive field properties of AII amacrine cells.Cell reports · 2023Article
- Article
- Lamin A upregulation reorganizes the genome during rod photoreceptor degeneration.Cell death & disease · 2023Article
- Rabconnectin-3α/DMXL2 Is Locally Enriched at the Synaptic Ribbon of Rod Photoreceptor Synapses.Cells · 2023Article
- Structural basis of calmodulin modulation of the rod cyclic nucleotide-gated channel.Proceedings of the National Academy of Sciences of the United States of America · 2023Article
- Why a Diffusing Single-Molecule can be Detected in Few Minutes by a Large Capturing Bioelectronic Interface.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2022Article
- Solo vs. Chorus: Monomers and Oligomers of Arrestin Proteins.International journal of molecular sciences · 2022Review
- Reproducibility of the Rod Photoreceptor Response Depends Critically on the Concentration of the Phosphodiesterase Effector Enzyme.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2022Article
- Analysis of waveform and amplitude of mouse rod and cone flash responses.The Journal of physiology · 2021Article
- Functional modulation of phosphodiesterase-6 by calcium in mouse rod photoreceptors.Scientific reports · 2021Article
- Article
- A biomimetic fly photoreceptor model elucidates how stochastic adaptive quantal sampling provides a large dynamic range.The Journal of physiology · 2017Review
- Article
- The evolution of rod photoreceptors.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2017Review
- Mutated olfactomedin 1 in the interphotoreceptor matrix of the mouse retina causes functional deficits and vulnerability to light damage.Histochemistry and cell biology · 2017Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors.
Funding
Abstract
Rod photoreceptors are among the most sensitive light detectors in nature. They achieve their remarkable sensitivity across a wide variety of species through a number of essential adaptations: a specialized cellular geometry, a G-protein cascade with an unusually stable receptor molecule, a low-noise transduction mechanism, a nearly perfect effector enzyme, and highly evolved mechanisms of feedback control and receptor deactivation. Practically any change in protein expression, enzyme activity, or feedback control can be shown to impair photon detection, either by decreasing sensitivity or signal-to-noise ratio, or by reducing temporal resolution. Comparison of mammals to amphibians suggests that rod outer-segment morphology and the molecules and mechanism of transduction may have evolved together to optimize light sensitivity in darkness, which culminates in the extraordinary ability of these cells to respond to single photons at the ultimate limit of visual perception.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.