ArticleEpilepsy research2015
Regional homogeneity (ReHo) changes in new onset versus chronic benign epilepsy of childhood with centrotemporal spikes (BECTS): A resting state fMRI study.
Article in Epilepsy research, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers.
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Who cites it
30 citing papers in PubMed.
- Functional connectivity in self-limited epilepsy with centrotemporal spikes increases with epilepsy duration and interictal spike exposure.Epilepsia · 2026Article
- Structure-function interrelationships and associated neurotransmitter profiles in drug-naïve benign childhood epilepsy with central-temporal spikes patients.European radiology · 2025Article
- Macroscale intrinsic dynamics are associated with microcircuit function in focal and generalized epilepsies.Communications biology · 2024Article
- Quantitative susceptibility mapping shows lower brain iron content in children with childhood epilepsy with centrotemporal spikes.Japanese journal of radiology · 2023Article
- Structural and functional changes in drug-naïve benign childhood epilepsy with centrotemporal spikes and their associated gene expression profiles.Cerebral cortex (New York, N.Y. : 1991) · 2023Article
- Activation Map Reveals Language Impairment in Children with Benign Epilepsy with Centrotemporal Spikes (BECTS).Neuropsychiatric disease and treatment · 2023Article
- Functional brain activity in patients with amnestic mild cognitive impairment: an rs-fMRI study.Frontiers in neurology · 2023Article
- Connectivity increases during spikes and spike-free periods in self-limited epilepsy with centrotemporal spikes.Clinical neurophysiology : official journal of the International Federation of Clinical Neurophysiology · 2022Article
- Brain functional and structural characteristics of patients with seizure recurrence following drug withdrawal.Neuroradiology · 2021Article
- Reliability and availability of granger causality density in localization of Rolandic focus in BECTS.Brain imaging and behavior · 2021Article
- Connectome-based prediction of brain age in Rolandic epilepsy: a protocol for a multicenter cross-sectional study.Annals of translational medicine · 2021Article
- Regional homogeneity abnormalities of resting state brain activities in children with growth hormone deficiency.Scientific reports · 2021Article
- Impact of Antiepileptic Drugs on Cognition and Neuromagnetic Activity in Childhood Epilepsy With Centrotemporal Spikes: A Magnetoencephalography Study.Frontiers in human neuroscience · 2021Article
- Different Functional Network Connectivity Patterns in Epilepsy: A Rest-State fMRI Study on Mesial Temporal Lobe Epilepsy and Benign Epilepsy With Centrotemporal Spike.Frontiers in neurology · 2021Article
- Aberrant Dynamics of Regional Coherence Measured by Resting-State fMRI in Children With Benign Epilepsy With Centrotemporal Spikes (BECTS).Frontiers in neurology · 2021Article
- Cell-Type-Specific Gene Modules Related to the Regional Homogeneity of Spontaneous Brain Activity and Their Associations With Common Brain Disorders.Frontiers in neuroscience · 2021Article
- Neural correlates of verbal working memory in children with epilepsy with centro-temporal spikes.NeuroImage. Clinical · 2020Article
- Altered Static and Dynamic Spontaneous Neural Activity in Drug-Naïve and Drug-Receiving Benign Childhood Epilepsy With Centrotemporal Spikes.Frontiers in human neuroscience · 2020Article
- The epileptic network and cognition: What functional connectivity is teaching us about the childhood epilepsies.Epilepsia · 2019Review
- Dysfunctional white-matter networks in medicated and unmedicated benign epilepsy with centrotemporal spikes.Human brain mapping · 2019Article
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Authors and funding
11 authors.
Funding
Abstract
objectiveThe purpose of this study was to investigate regional homogeneity (ReHo) in children with new-onset drug-naïve Benign Epilepsy with Centrotemporal Spikes (BECTS), chronic BECTS and healthy controls (HC) using the Regional Homogeneity (ReHo) method applied to resting state fMRI data.
methodsResting state fMRI data was collected from three groups of children aged 6-13, including new onset drug naïve BECTS, chronic BECTS with medication, and HC; the data analyzed by ReHo method. Mandarin school exams scores were acquired and compared across groups.
resultsThere were three main findings. Firstly, compared with HC, abnormally increased ReHo was observed in bilateral sensorimotor regions in new onset BECTS which normalized or even reversed in the chronic BECTS group. Secondly, enhanced ReHo was found in the left frontal language region in the two BECTS groups, with even higher ReHo value in the chronic group. Lastly, decreased ReHo was found in regions of the default mode network (DMN), bilateral occipital lobes and cerebellum in both the new onset and chronic BECTS groups, lower in chronic BECTS. Behavioral analyses of school scores showed the chronic BECTS group presented significantly lower scores compared to HC (p<.05). SIGNIFICANCE: The coherence of low frequency fluctuations is disrupted in sensorimotor, language and DMN-related regions in new-onset BECTS. Some of these effects seem to be selectively normalized in chronic BECTS, thus allowing us to explore possible chronicity and AED-induced effects on BECTS. Abnormal ReHo in left language and DMN regions could be responsible for impairments of cognitive function.
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