ArticleProceedings of the National Academy of Sciences of the United States of America2015
Ion channel degeneracy enables robust and tunable neuronal firing rates.
Article in Proceedings of the National Academy of Sciences of the United States of America, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 68 papers.
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68 citing papers in PubMed.
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- Plasticity in voltage-gated ion channels following overwintering in respiratory motoneurons of American bullfrogs.The Journal of experimental biology · 2025Article
- Biophysical modelling of intrinsic cardiac nervous system neuronal electrophysiology based on single-cell transcriptomics.The Journal of physiology · 2025Article
- Focused Ultrasound Modulates Dopamine in a Mesolimbic Reward Circuit.Journal of neurochemistry · 2025Article
- Review
- Mild focal cooling selectively impacts computations in dendritic trees.bioRxiv : the preprint server for biology · 2024Article
- Neural Processing without OPhysiology (Bethesda, Md.) · 2024Review
- Dimensionality reduction of neuronal degeneracy reveals two interfering physiological mechanisms.PNAS nexus · 2024Article
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- Alterations in network robustness upon simultaneous temperature and pH perturbations.Journal of neurophysiology · 2024Article
- Robust and consistent measures of pattern separation based on information theory and demonstrated in the dentate gyrus.PLoS computational biology · 2024Article
- IThe Journal of physiology · 2023Article
- A universal workflow for creation, validation, and generalization of detailed neuronal models.Patterns (New York, N.Y.) · 2023Article
- Article
8 more citing papers are in PubMed but not listed here.
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3 authors.
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Abstract
Firing rate is an important means of encoding information in the nervous system. To reliably encode a wide range of signals, neurons need to achieve a broad range of firing frequencies and to move smoothly between low and high firing rates. This can be achieved with specific ionic currents, such as A-type potassium currents, which can linearize the frequency-input current curve. By applying recently developed mathematical tools to a number of biophysical neuron models, we show how currents that are classically thought to permit low firing rates can paradoxically cause a jump to a high minimum firing rate when expressed at higher levels. Consequently, achieving and maintaining a low firing rate is surprisingly difficult and fragile in a biological context. This difficulty can be overcome via interactions between multiple currents, implying a need for ion channel degeneracy in the tuning of neuronal properties.
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