ArticleProceedings of the National Academy of Sciences of the United States of America2015
Population, genetic, and antigenic diversity of the apicomplexan Eimeria tenella and their relevance to vaccine development.
Article in Proceedings of the National Academy of Sciences of the United States of America, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 65 papers.
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Who cites it
65 citing papers in PubMed, 122 citations in OpenAlex.
- A yeast-based oral vaccine platform reveals antigen-dependent protection against Eimeria tenella.Poultry science · 2026Article
- Pathogenic mechanism of Eimeria tenella EtMIC2 promotes Eimeria tenella invasion and inhibits host cell apoptosis through binding to the ITGAV receptor.Poultry science · 2026Article
- Genetic diversity inVeterinary world · 2026Review
- Antioxidant, anticoccidial, and toxicological evaluation of Ocimum gratissimum and Vernonia amygdalina leaf extracts against Eimeria spp.Scientific reports · 2026Article
- Environmental surveillance: harnessing environmental sample data to protect animal health.Frontiers in veterinary science · 2026Review
- Sophora flavescens Aqueous Extract Suppresses Eimeria tenella-Induced Inflammatory Responses and Regulates MAPK Pathway.Poultry science · 2025Article
- Simultaneous Detection and Differentiation of FourAnimals : an open access journal from MDPI · 2025Article
- Vaccinations and Functional Feed Supplements as Alternatives to Coccidiostats for the Control of Coccidiosis in Raising Broiler Chickens.Animals : an open access journal from MDPI · 2025Review
- Genome assembly and annotation of Babesia rossi, a protozoan parasite for canine babesiosis.BMC genomics · 2025Article
- A chromosome-scale genome assembly of Giardia duodenalis by long-read sequencing of ten trophozoites.Scientific data · 2025Article
- Characterization of the Antigenic and Immunogenic Properties of the Gametocyte Antigen 56 fromAnimals : an open access journal from MDPI · 2025Article
- Comparative efficacy of commonly used herbal and orthodox anticoccidial drugs in broiler birds experimentally infected with mixed Eimeria species.Tropical animal health and production · 2025Article
- Molecular mechanisms of surface antigen suppression by ApiAP2 and its implications for vaccine development.Veterinary research · 2025Article
- Molecular and histopathological characterization ofFrontiers in veterinary science · 2025Article
- Study of dense granule proteins inFrontiers in immunology · 2025Article
- Eimeria: Navigating complex intestinal ecosystems.PLoS pathogens · 2024Review
- Insights into genomic sequence diversity of the SAG surface antigen superfamily in geographically diverse Eimeria tenella isolates.Scientific reports · 2024Article
- Multi-omics analysis reveals regime shifts in the gastrointestinal ecosystem in chickens following anticoccidial vaccination andmSystems · 2024Article
- Prevalence, geographic distribution and risk factors of Eimeria species on commercial broiler farms in Guangdong, China.BMC veterinary research · 2024Article
- Effects of dietary water-soluble extract of rosemary supplementation on growth performance and intestinal health of broilers infected with Eimeria tenella.Journal of animal science · 2024Article
5 more citing papers are in PubMed but not listed here.
Corrections and comments
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Authors and funding
19 authors at 11 institutions in 6 countries.
Funding
Abstract
The phylum Apicomplexa includes serious pathogens of humans and animals. Understanding the distribution and population structure of these protozoan parasites is of fundamental importance to explain disease epidemiology and develop sustainable controls. Predicting the likely efficacy and longevity of subunit vaccines in field populations relies on knowledge of relevant preexisting antigenic diversity, population structure, the likelihood of coinfection by genetically distinct strains, and the efficiency of cross-fertilization. All four of these factors have been investigated for Plasmodium species parasites, revealing both clonal and panmictic population structures with exceptional polymorphism associated with immunoprotective antigens such as apical membrane antigen 1 (AMA1). For the coccidian Toxoplasma gondii only genomic diversity and population structure have been defined in depth so far; for the closely related Eimeria species, all four variables are currently unknown. Using Eimeria tenella, a major cause of the enteric disease coccidiosis, which exerts a profound effect on chicken productivity and welfare, we determined population structure, genotype distribution, and likelihood of cross-fertilization during coinfection and also investigated the extent of naturally occurring antigenic diversity for the E. tenella AMA1 homolog. Using genome-wide Sequenom SNP-based haplotyping, targeted sequencing, and single-cell genotyping, we show that in this coccidian the functionality of EtAMA1 appears to outweigh immune evasion. This result is in direct contrast to the situation in Plasmodium and most likely is underpinned by the biology of the direct and acute coccidian life cycle in the definitive host.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.