ArticleJournal of assisted reproduction and genetics2015
Analysis of the correlation of CATSPER single nucleotide polymorphisms (SNPs) with idiopathic asthenospermia.
Article in Journal of assisted reproduction and genetics, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
What it found
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Who cites it
10 citing papers in PubMed, 17 citations in OpenAlex.
- <p>Echinacoside alleviates asthenozoospermia by upregulating Sox5‑mediated transcriptional activation of the CatSper gene</p>.Molecular medicine reports · 2026Article
- Characteristics of gut microbiota in patients with asthenozoospermia: a Chinese pilot study.BMC microbiology · 2024Article
- Review
- Article
- Association of CATSPER1, SPATA16 and TEX11 genes polymorphism with idiopathic azoospermia and oligospermia risk in Iranian population.BMC medical genomics · 2022Article
- Steroidal Antagonists of Progesterone- and Prostaglandin EMolecular pharmacology · 2022Article
- Association ofBioscience reports · 2019Article
- Associations between DNAH1 gene polymorphisms and male infertility: A retrospective study.Medicine · 2018Article
- Ion channel gene expressions in infertile men: A case-control study.International journal of reproductive biomedicine · 2017Article
- Expression Analysis of the CRISP2, CATSPER1, PATE1 and SEMG1 in the Sperm of Men with Idiopathic Asthenozoospermia.Journal of reproduction & infertilityArticle
Corrections and comments
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Authors and funding
10 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
purposeIdiopathic asthenospermia is the most common type of male infertility. Although the mechanisms causing asthenospermia are complex, recent studies have indicated an important role of cation channel of sperm (CATSPER) gene downregulation or abnormality in the etiology of idiopathic asthenospermia.
methodsIn the present study, 192 patients with idiopathic asthenospermia and 288 healthy controls were enrolled, and a flight mass spectrometry using Sequenom's MassArray biochip system was applied for genotyping 16 CATSPER gene SNPs reported in the human single nucleotide polymorphism (SNP) database.
resultsOur results indicated a correlation between CATSPER1 SNPs and idiopathic asthenospermia. In particular, the exonal SNP rs1893316 in CATSPER1 significantly correlated with idiopathic asthenospermia risk and is a potential important factor in determining an individual's genetic susceptibility to idiopathic asthenospermia.
conclusionThese finding will help to further elucidate the role of CATSPER1 in idiopathic asthenospermia pathogenesis.
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