ArticleThe Korean journal of internal medicine2015
Replication of the results of genome-wide and candidate gene association studies on telomere length in a Korean population.
Article in The Korean journal of internal medicine, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
18 citing papers in PubMed, 26 citations in OpenAlex.
- Effects of Hawthorn Fruit Supplementation on Facial Skin Phenotypes and Leukocyte Telomere Length Stratified byNutrients · 2025Trial
- rs2736098, a synonymous polymorphism, is associated with carcinogenesis and cell count in multiple tissue types by regulatingHeliyon · 2024Article
- Associations betweenBiomedicines · 2024Article
- Article
- Article
- Review
- Article
- The association of telomere maintenance and TERT expression with susceptibility to human papillomavirus infection in cervical epithelium.Cellular and molecular life sciences : CMLS · 2022Article
- Large-scale cross-cancer fine-mapping of the 5p15.33 region reveals multiple independent signals.HGG advances · 2021Article
- A genetic variant in telomerase reverse transcriptase (TERT) modifies cancer risk in Lynch syndrome patients harbouring pathogenic MSH2 variants.Scientific reports · 2021Article
- Construction of JRG (Japanese reference genome) with single-molecule real-time sequencing.Human genome variation · 2019Article
- Candidate susceptibility variants in angioimmunoblastic T-cell lymphoma.Familial cancer · 2019Article
- The contribution of parent-to-offspring transmission of telomeres to the heritability of telomere length in humans.Human genetics · 2019Article
- Association ofOncotarget · 2018Article
- Article
- Genome-wide association study of telomere length among South Asians identifies a second RTEL1 association signal.Journal of medical genetics · 2018Article
- Confirmation of five novel susceptibility loci for systemic lupus erythematosus (SLE) and integrated network analysis of 82 SLE susceptibility loci.Human molecular genetics · 2017Article
- TERT Polymorphism rs2853669 Influences on Lung Cancer Risk in the Korean Population.Journal of Korean medical science · 2015Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
11 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
BACKGROUND/
aimsA number of genome-wide and candidate gene association studies have identified polymorphisms associated with telomere length in Caucasian populations. This study was conducted to determine the impacts of 17 polymorphisms identified in Caucasians on telomere length in a Korean population.
methodsNinety-four healthy individuals were enrolled in this study. Relative telomere length of chromosomes from peripheral blood samples was measured using quantitative polymerase chain reaction.
resultsTwo polymorphisms, rs10936599 of MYNN and rs412658 of ZNF676, were found to be associated w ith telomere length (under dominant model, p = 0.04; under recessive model, p = 0.001). Three polymorphisms, rs2853669, rs7705526, and rs2736108, at the TERT locus were also associated with telomere length (under recessive model, p = 0.01, p = 0.02, and p = 0.01, respectively). The genotypes of the five polymorphisms associated with short telomere length were considered bad genotypes; telomere length was significantly decreased with increasing number of bad genotypes (p= 1.7 × 10(-5)).
conclusionsWe have identified polymorphisms associated with telomere length in a Korean population.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.