ReviewThe Korean journal of internal medicine2015
A systematic approach for the diagnosis and treatment of idiopathic peptic ulcers.
Review in The Korean journal of internal medicine, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers, 1 of them a synthesis that pooled it.
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Who cites it
25 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Bibliometric and visualisation analyses of gastric ulcer knowledge areas and emerging trends, 2004-2024.Frontiers in medicine · 2025Pooled it
- Treatment outcomes and determinants of refractory peptic ulcer disease in children: A prospective study from Vietnam.Journal of pediatric gastroenterology and nutrition · 2026Article
- A Case of a Perforated Duodenal Ulcer in the Context of Acute Tubular Necrosis and Urosepsis.Cureus · 2025Article
- Unravelling Peptic Ulcers: Comprehensive Insights into Etiology, Diagnosis, Screening Techniques, and Treatment.Current pharmaceutical design · 2025Review
- Article
- Coinfection of cytomegalovirus and strongyloidiasis presenting as massive gastrointestinal bleeding in an immunocompromised host: a case report.Frontiers in medicine · 2024Article
- Background factors of idiopathic peptic ulcers and optimal treatment methods: a multicenter retrospective Japanese study.Journal of clinical biochemistry and nutrition · 2024Article
- Changing trends and characteristics of peptic ulcer disease: A multicenter study from 2010 to 2019 in Korea.World journal of gastroenterology · 2023Article
- Phenolic Characterization Using cLC-DAD Analysis and Evaluation of In Vitro and In Vivo Pharmacological Activities ofAntioxidants (Basel, Switzerland) · 2022Article
- Economic and health impacts of Helicobacter pylori eradication strategy for the treatment of peptic ulcer disease: A cost-effectiveness analysis.Helicobacter · 2022Article
- Mechanism of Traditional Tibetan Medicine Grubthobrildkr Alleviated Gastric Ulcer Induced by Acute Systemic Hypoxia in Rats.BioMed research international · 2022Article
- New Trends and Advances in Non-Variceal Gastrointestinal Bleeding-Series II.Journal of clinical medicine · 2021Review
- Article
- Role of the antioxidant properties in the gastroprotective and gastric healing activity promoted by Brazilian green propolis and the healing efficacy of Artepillin C.Inflammopharmacology · 2020Article
- Clinical comparative analysis of various duodenal diseases in different age groups.The Turkish journal of gastroenterology : the official journal of Turkish Society of Gastroenterology · 2020Article
- Enzyme Inhibitory Kinetics and Molecular Docking Studies of Halo-Substituted Mixed Ester/Amide-Based Derivatives as Jack Bean Urease Inhibitors.BioMed research international · 2020Article
- Changes of gastric ulcer bleeding in the metropolitan area of Japan.World journal of gastroenterology · 2019Article
- Is the new potent acid-inhibitory drug vonoprazan effective for healing idiopathic peptic ulcers? A multicenter observational study in Akita Prefecture, Japan.Journal of gastroenterology · 2019Observational
- Protective activity of geraniol against acetic acid andJournal of traditional and complementary medicine · 2019Article
- Refractory gastric antral ulcers without Helicobacter pylori infection and non-steroidal anti-inflammatory drugs.Clinical journal of gastroenterology · 2018Article
Corrections and comments
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Authors and funding
3 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
An idiopathic peptic ulcer is defined as an ulcer with unknown cause or an ulcer that appears to arise spontaneously. The first step in treatment is to exclude common possible causes, including Helicobacter pylori infection, infection with other pathogens, ulcerogenic drugs, and uncommon diseases with upper gastrointestinal manifestations. When all known causes are excluded, a diagnosis of idiopathic peptic ulcer can be made. A patient whose peptic ulcer is idiopathic may have a higher risk for complicated ulcer disease, a poorer response to gastric acid suppressants, and a higher recurrence rate after treatment. Risk factors associated with this disease may include genetic predisposition, older age, chronic mesenteric ischemia, smoking, concomitant diseases, a higher American Society of Anesthesiologists score, and higher stress. Therefore, the diagnosis and management of emerging disease should systematically explore all known causes and treat underlying disease, while including regular endoscopic surveillance to confirm ulcer healing and the use of proton-pump inhibitors on a case-by-case basis.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.