ArticleScientific reports2015
Systematic stereoscopic analyses for cloacal development: The origin of anorectal malformations.
Article in Scientific reports, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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17 citing papers in PubMed, 37 citations in OpenAlex.
- Spatiotemporal remodelling of the cloacal region determines the position of the anal opening in mouse embryos.Journal of anatomy · 2026Article
- The cloacal outgrowth orchestrates co-development of the bladder and umbilical arteries.Development (Cambridge, England) · 2026Article
- Differentiation of human pluripotent stem cells into urothelial organoids via transient activation of WNT signaling.iScience · 2025Article
- Epithelial and mesenchymal compartments of the developing bladder and urethra display spatially distinct gene expression patterns.Developmental biology · 2025Article
- Article
- Sagittal septum duplication of bladder and duplication of posterior urethra combined with congenital megacolon: a case report and literature review.BMC urology · 2024Review
- Generation of Urothelial Cells from Mouse-Induced Pluripotent Stem Cells.International journal of stem cells · 2022Article
- HSPA6 and its role in cancers and other diseases.Molecular biology reports · 2022Review
- Development of Surgical and Visualization Procedures to Analyze Vasculatures by Mouse Tail Edema Model.Biological procedures online · 2021Article
- Pathogenesis of Anorectal Malformations in Retinoic Acid Receptor Knockout Mice Studied by HREM.Biomedicines · 2021Article
- [Diagnosis and treatment of ankyloglossia in newborns and infants].Hua xi kou qiang yi xue za zhi = Huaxi kouqiang yixue zazhi = West China journal of stomatology · 2020Review
- Duplex kidney formation: developmental mechanisms and genetic predisposition.F1000Research · 2020Review
- Directed differentiation of human induced pluripotent stem cells into mature stratified bladder urothelium.Scientific reports · 2019Article
- HSPA6: A new autosomal recessive candidate gene for the VATER/VACTERL malformation spectrum.Birth defects research · 2019Article
- The development of the cloaca in the human embryo.Journal of anatomy · 2018Article
- Microarray analysis of miRNAs during hindgut development in rat embryos with ethylenethiourea‑induced anorectal malformations.International journal of molecular medicine · 2018Article
- Epithelial-mesenchymal transformation and apoptosis in rat urethra development.Pediatric research · 2017Article
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Authors and funding
8 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The division of the embryonic cloaca is the most essential event for the formation of digestive and urinary tracts. The defective development of the cloaca results in anorectal malformations (ARMs; 2-5 per 10,000 live births). However, the developmental and pathogenic mechanisms of ARMs are unclear. In the current study, we visualized the epithelia in the developing cloaca and nephric ducts (NDs). Systemic stereoscopic analyses revealed that the ND-cloaca connection sites shifted from the lateral-middle to dorsal-anterior part of the cloaca during cloacal division from E10.5 to E11.5 in mouse embryos. Genetic cell labeling analyses revealed that the cells in the ventral cloacal epithelium in the early stages rarely contributed to the dorsal part. Moreover, we revealed the possible morphogenetic movement of endodermal cells within the anterior part of the urogenital sinus and hindgut. These results provide the basis for understanding both cloacal development and the ARM pathogenesis.
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