Evidence map›Paper›PMID 26353940›Full record

ArticleNature communications2015

Blood coagulation protein fibrinogen promotes autoimmunity and demyelination via chemokine release and antigen presentation.

Jae Kyu Ryu, Mark A Petersen, Sara G Murray, Kim M Baeten, Anke Meyer-Franke, Justin P Chan, Eirini Vagena, Catherine Bedard, Michael R Machado, Pamela E Rios Coronado and 6 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Nature communications, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 178 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
178citing papers in PubMed, 2 pooled it
14.1field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

178 citing papers in PubMed, 2 syntheses or guidelines pooled it, 272 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
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  4. Review
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  7. Article
  8. Article
  9. Controllability Analysis of Intercellular Protein-Protein Interaction Networks.Computational and structural biotechnology journal · 2026
    Article
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  18. Biomaterial-Based Therapeutic Delivery of Immune Cells.Advanced healthcare materials · 2025
    Review
  19. Review
  20. Article

118 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

16 authors at 4 institutions in 3 countries.

Jae Kyu RyuGladstone Institute of Neurological Disease, University of California, San Francisco, California 94158, USA.
Mark A PetersenGladstone Institute of Neurological Disease, University of California, San Francisco, California 94158, USA.
Sara G MurrayGladstone Institute of Neurological Disease, University of California, San Francisco, California 94158, USA.
Kim M BaetenGladstone Institute of Neurological Disease, University of California, San Francisco, California 94158, USA.
Anke Meyer-FrankeGladstone Institute of Neurological Disease, University of California, San Francisco, California 94158, USA.
Justin P ChanGladstone Institute of Neurological Disease, University of California, San Francisco, California 94158, USA.
Eirini VagenaGladstone Institute of Neurological Disease, University of California, San Francisco, California 94158, USA.
Catherine BedardGladstone Institute of Neurological Disease, University of California, San Francisco, California 94158, USA.
Michael R MachadoGladstone Institute of Neurological Disease, University of California, San Francisco, California 94158, USA.
Pamela E Rios CoronadoGladstone Institute of Neurological Disease, University of California, San Francisco, California 94158, USA.
Thomas Prod'hommeDepartment of Neurology, University of California San Francisco, San Francisco, California 94143, USA.
Israel F CharoGladstone Institute of Cardiovascular Disease, University of California, San Francisco, California 94158, USA.
Hans LassmannCentre for Brain Research, Medical University of Vienna, Vienna A-1090, Austria.
Jay L DegenDivision of Experimental Hematology, Cincinnati Children's Hospital Research Foundation and University of Cincinnati College of Medicine, Cincinnati, Ohio 45229, USA.
Scott S ZamvilDepartment of Neurology, University of California San Francisco, San Francisco, California 94143, USA.
Katerina AkassoglouGladstone Institute of Neurological Disease, University of California, San Francisco, California 94158, USA.ORCID http://orcid.org/0000-0002-2632-1465
Gladstone Institutes · USUniversity of California, San Francisco · USCincinnati Children's Hospital Medical Center · USMedical University of Vienna · AT

Funding

Translational InformaticsP30CA082103 · NCI · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI Jennifer Leigh Clarke · 1999 to 2026
$209.7M
Virology CoreP30AI027763 · NIAID · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI STEVEN Grant DEEKS · 1988 to 2026
$93.6M
Pediatric Scientist Development Program (PSDP) [K12]K12HD000850 · NICHD · YALE UNIVERSITY · PI Sallie R. Permar · 1987 to 2026
$44.1M
Mechanisms of Fibrin Action in Multiple SclerosisR01NS052189 · NINDS · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI AKASSOGLOU, KATERINA · 2005 to 2016
$5.1M
Child Health Career Development Program at UCSFK12HD072222 · NICHD · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI FERRIERO, DONNA M. · 2013 to 2017
$2.0M
B cells in CNS autoimmunityR01AI073737 · NIAID · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI ZAMVIL, SCOTT S · 2009 to 2013
$1.9M
CCR2 in Hematopoietic Stem Cell Homing, Macrophage Polarization and Organ RepairR01HL102475 · NHLBI · J. DAVID GLADSTONE INSTITUTES · PI CHARO, ISRAEL F. · 2011 to 2014
$1.9M
Thrombin-mediated proteolysis in neuroinflammatory diseaseR01HL096126 · NHLBI · CINCINNATI CHILDRENS HOSP MED CTR · PI DEGEN, JAY L · 2009 to 2012
$1.5M
Regulatory monocytes in CNS autoimmune diseaseR01NS063008 · NINDS · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI ZAMVIL, SCOTT S · 2009 to 2013
$1.3M
Howard Hughes Medical InstituteNCI NIH HHS CA082103NCI NIH HHS P30 CA082103NHLBI NIH HHS HL096126NHLBI NIH HHS HL102475NHLBI NIH HHS R01 HL096126NHLBI NIH HHS R01 HL102475NIAID NIH HHS P30 AI027763NIAID NIH HHS R01 AI073737NICHD NIH HHS K12 HD000850NICHD NIH HHS K12 HD072222NINDS NIH HHS R01 NS052189NINDS NIH HHS R01 NS063008
6 · The paper itself

Abstract

Autoimmunity and macrophage recruitment into the central nervous system (CNS) are critical determinants of neuroinflammatory diseases. However, the mechanisms that drive immunological responses targeted to the CNS remain largely unknown. Here we show that fibrinogen, a central blood coagulation protein deposited in the CNS after blood-brain barrier disruption, induces encephalitogenic adaptive immune responses and peripheral macrophage recruitment into the CNS leading to demyelination. Fibrinogen stimulates a unique transcriptional signature in CD11b(+) antigen-presenting cells inducing the recruitment and local CNS activation of myelin antigen-specific Th1 cells. Fibrinogen depletion reduces Th1 cells in the multiple sclerosis model, experimental autoimmune encephalomyelitis. Major histocompatibility complex (MHC) II-dependent antigen presentation, CXCL10- and CCL2-mediated recruitment of T cells and macrophages, respectively, are required for fibrinogen-induced encephalomyelitis. Inhibition of the fibrinogen receptor CD11b/CD18 protects from all immune and neuropathologic effects. Our results show that the final product of the coagulation cascade is a key determinant of CNS autoimmunity.

Indexed as

Adaptive ImmunityAnimalsAntigen PresentationAutoimmunityBlood-Brain BarrierBrainCD11b AntigenCell ProliferationChemokine CCL2Chemokine CXCL10ChemokinesCX3C Chemokine Receptor 1Demyelinating DiseasesDNA-Binding ProteinsEncephalomyelitis, Autoimmune, ExperimentalFibrinCcl2 protein, mouseCD11b AntigenChemokine CCL2Chemokine CXCL10ChemokinesCX3C Chemokine Receptor 1Cx3cr1 protein, mouseCxcl10 protein, mouseDNA-Binding ProteinsFibrinFibrinogenHomeodomain ProteinsMyelin-Oligodendrocyte GlycoproteinRAG-1 proteinRag2 protein, mouseReceptors, Antigen, T-CellReceptors, Chemokine

Identifiers

PMID26353940
PMCPMC4579523
OpenAlexW2257620318

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.