Evidence map›Paper›PMID 26353920›Full record

ArticleScientific reports2015

Transdermal neuromodulation of noradrenergic activity suppresses psychophysiological and biochemical stress responses in humans.

William J Tyler, Alyssa M Boasso, Hailey M Mortimore, Rhonda S Silva, Jonathan D Charlesworth, Michelle A Marlin, Kirsten Aebersold, Linh Aven, Daniel Z Wetmore, Sumon K Pal

Registry-linked trialOpen access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Scientific reports, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT03859336 (High-Frequency Transdermal Neuromodulation to Decrease Anxiety and Improve Sleep in Autism Spectrum Disorder), which is not on this map. Cited by 26 papers.

0numbers the graph read from it
0cells of the map it votes in
26citing papers in PubMed
4.3field-weighted citation impact, top 6% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT03859336 nacompletednot on this mapstarted 2019, after this paper: background citation

High-Frequency Transdermal Neuromodulation to Decrease Anxiety and Improve Sleep in Autism Spectrum Disorder (ASD)

TypeinterventionalSponsorPhoenix Children's HospitalRan2019 to 2021Enrolled10ConditionsAutism Spectrum DisorderArmsTransdermal Neuromodulation Stimulation
3 · Its place in the literature

Who cites it

26 citing papers in PubMed, 73 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 1 institution in 1 country.

William J TylerThync, Inc. Boston, MA 02199, USA.
Alyssa M BoassoThync, Inc. Boston, MA 02199, USA.
Hailey M MortimoreThync, Inc. Boston, MA 02199, USA.
Rhonda S SilvaThync, Inc. Boston, MA 02199, USA.
Jonathan D CharlesworthThync, Inc. Boston, MA 02199, USA.
Michelle A MarlinThync, Inc. Boston, MA 02199, USA.
Kirsten AebersoldThync, Inc. Boston, MA 02199, USA.
Linh AvenThync, Inc. Boston, MA 02199, USA.
Daniel Z WetmoreThync, Inc. Boston, MA 02199, USA.
Sumon K PalThync, Inc. Boston, MA 02199, USA.
Thync (United States) · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

We engineered a transdermal neuromodulation approach that targets peripheral (cranial and spinal) nerves and utilizes their afferent pathways as signaling conduits to influence brain function. We investigated the effects of this transdermal electrical neurosignaling (TEN) method on sympathetic physiology under different experimental conditions. The TEN method involved delivering high-frequency pulsed electrical currents to ophthalmic and maxillary divisions of the right trigeminal nerve and cervical spinal nerve afferents. Under resting conditions, TEN significantly suppressed basal sympathetic tone compared to sham as indicated by functional infrared thermography of facial temperatures. In a different experiment, subjects treated with TEN reported significantly lower levels of tension and anxiety on the Profile of Mood States scale compared to sham. In a third experiment when subjects were experimentally stressed TEN produced a significant suppression of heart rate variability, galvanic skin conductance, and salivary α-amylase levels compared to sham. Collectively these observations demonstrate TEN can dampen basal sympathetic tone and attenuate sympathetic activity in response to acute stress induction. Our physiological and biochemical observations are consistent with the hypothesis that TEN modulates noradrenergic signaling to suppress sympathetic activity. We conclude that dampening sympathetic activity in such a manner represents a promising approach to managing daily stress.

Indexed as

Stress, PhysiologicalStress, PsychologicalAffectalpha-AmylasesBiomarkersCognitionElectric StimulationFemaleHeart RateHumansHydrocortisoneMalePsychomotor PerformanceReaction TimeSalivaSkinalpha-AmylasesBiomarkersHydrocortisone

Identifiers

PMID26353920
PMCPMC4564766
OpenAlexW2160209381

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.