Evidence map›Paper›PMID 26353789›Full record

Trial reportAnnals of the rheumatic diseases2016

Fish oil in knee osteoarthritis: a randomised clinical trial of low dose versus high dose.

Catherine L Hill, Lynette M March, Dawn Aitken, Susan E Lester, Ruth Battersby, Kristen Hynes, Tanya Fedorova, Susanna M Proudman, Michael James, Leslie G Cleland and 1 more

Open access · bronzeAbstract readMulticenter StudyRandomized Controlled Trial
PubMed Publisher
In one paragraph

Trial report in Annals of the rheumatic diseases, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 72 papers, 11 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
72citing papers in PubMed, 11 pooled it
11.0field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

72 citing papers in PubMed, 11 syntheses or guidelines pooled it, 142 citations in OpenAlex.

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  18. Supplementation with omega-3 fish oil has no effect on bone mineral density in adults with knee osteoarthritis: a 2-year randomized controlled trial.Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA · 2016
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12 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

11 authors at 4 institutions in 1 country.

Catherine L HillRheumatology Unit, The Queen Elizabeth Hospital, Woodville, South Australia University of Adelaide, The Health Observatory, Adelaide, South Australia.
Lynette M MarchRoyal North Shore Hospital, Institute of Bone and Joint Research, St Leonards, New South Wales, Australia.
Dawn AitkenMenzies Research Institute, Hobart, Tasmania, Australia.
Susan E LesterRheumatology Unit, The Queen Elizabeth Hospital, Woodville, South Australia.
Ruth BattersbyRheumatology Unit, The Queen Elizabeth Hospital, Woodville, South Australia.
Kristen HynesMenzies Research Institute, Hobart, Tasmania, Australia.
Tanya FedorovaRoyal North Shore Hospital, Institute of Bone and Joint Research, St Leonards, New South Wales, Australia.
Susanna M ProudmanRheumatology Unit, Royal Adelaide Hospital, Adelaide, South Australia.
Michael JamesRheumatology Unit, Royal Adelaide Hospital, Adelaide, South Australia.
Leslie G ClelandRheumatology Unit, Royal Adelaide Hospital, Adelaide, South Australia.
Graeme JonesMenzies Research Institute, Hobart, Tasmania, Australia.
Menzies School of Health Research · AURoyal Adelaide Hospital · AUQueen Elizabeth Hospital · AURoyal North Shore Hospital · AU

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectivesTo determine whether high-dose fish oil is superior to low-dose supplementation for symptomatic and structural outcomes in knee osteoarthritis (OA).

methodsA randomised, double-blind, multicentre trial enrolled 202 patients with knee OA and regular knee pain. They were randomised 1:1 to high-dose fish oil (4.5 g omega-3 fatty acids) 15 mL/day or (2) low-dose fish oil (blend of fish oil and sunola oil; ratio of 1:9, 0.45 g omega-3 fatty acids) 15 mL/day. The primary endpoints were Western Ontario and McMaster Universities Arthritis Index (WOMAC) pain score at 3, 6, 12 and 24 months, and change in cartilage volume at 24 months. Secondary outcomes included WOMAC function, quality of life, analgesic and non-steroidal anti-inflammatory drug use and bone marrow lesion score.

resultsAlthough there was improvement in both groups, the low-dose fish oil group had greater improvement in WOMAC pain and function scores at 2 years compared with the high-dose group, whereas between-group differences at 1 year did not reach statistical significance. There was no difference between the two groups in cartilage volume loss at 2 years. For other secondary endpoints, there was no difference between the two groups at 2 years.

conclusionsIn people with symptomatic knee OA, there was no additional benefit of a high-dose fish oil compared with low-dose fish oil. The combination comparator oil appeared to have better efficacy in reducing pain at 2 years, suggesting that this requires further investigation. TRIAL REGISTRATION NUMBER: Australian New Zealand Clinical Trials Registry (ACTRN 12607000415404).

Indexed as

AcetaminophenAgedAnalgesicsAnti-Inflammatory Agents, Non-SteroidalArthralgiaCartilage, ArticularDietary SupplementsDouble-Blind MethodFatty Acids, Omega-3FemaleHumansMagnetic Resonance ImagingMaleMiddle AgedMusculoskeletal PainOrgan SizeAcetaminophenAnalgesicsAnti-Inflammatory Agents, Non-SteroidalFatty Acids, Omega-3EpidemiologyKnee OsteoarthritisTreatment

Identifiers

PMID26353789
OpenAlexW1924450381

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.