ArticleJournal of lipid research2015
Flexible origin of hydrocarbon/pheromone precursors in Drosophila melanogaster.
Article in Journal of lipid research, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 55 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
55 citing papers in PubMed, 136 citations in OpenAlex.
- Lipid metabolism of hepatocyte-like cells supports intestinal tumor growth in Drosophila.Nature communications · 2026Article
- MicroRNA-375-3p Targets Fatty Acid Synthase and Relish to Regulate Energy Allocation During Pupal Metamorphosis and Starvation.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026Article
- Lipid Metabolism in Relation to Carbohydrate Metabolism.Advances in experimental medicine and biology · 2026Review
- Insect Lipids: Structure, Classification and Function.Advances in experimental medicine and biology · 2026Review
- Dietary Lipids and Their Metabolism in the Midgut.Advances in experimental medicine and biology · 2026Review
- Lipid Metabolism in Insect Vectors of Diseases.Advances in experimental medicine and biology · 2026Review
- Endocrine Control of Lipid Metabolism.Advances in experimental medicine and biology · 2026Review
- Differences among populations and changes during domestication in the lipidome of Queensland fruit fly.BMC ecology and evolution · 2025Article
- Co-Occurring Sister Taxa of Mountain Butterflies Exhibit Distinct Cuticular Hydrocarbon Profiles.Ecology and evolution · 2025Article
- Article
- Insulin/insulin-like growth factor signaling pathway promotes higher fat storage inbioRxiv : the preprint server for biology · 2025Article
- Regulatory changes in the fatty acid elongase eloF underlie the evolution of sex-specific pheromone profiles in Drosophila prolongata.BMC biology · 2025Article
- Identification of Fatty Acid Synthase inInsects · 2025Article
- Knockdown ofInsects · 2025Article
- Regulatory Changes in the Fatty Acid ElongasebioRxiv : the preprint server for biology · 2024Article
- Chemical and transcriptomic diversity do not correlate with ascending levels of social complexity in the insect order Blattodea.Ecology and evolution · 2024Article
- Complexity of Chemical Emissions Increases Concurrently with Sexual Maturity in Heliconius Butterflies.Journal of chemical ecology · 2024Article
- Germline proliferation trades off with lipid metabolism inEvolution letters · 2024Article
- A fatty acid anabolic pathway in specialized-cells sustains a remote signal that controls egg activation in Drosophila.PLoS genetics · 2024Article
- Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
9 authors at 6 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
In terrestrial insects, cuticular hydrocarbons (CHCs) provide protection from desiccation. Specific CHCs can also act as pheromones, which are important for successful mating. Oenocytes are abdominal cells thought to act as specialized units for CHC biogenesis that consists of long-chain fatty acid (LCFA) synthesis, optional desaturation(s), elongation to very long-chain fatty acids (VLCFAs), and removal of the carboxyl group. By investigating CHC biogenesis in Drosophila melanogaster, we showed that VLCFA synthesis takes place only within the oenocytes. Conversely, several pathways, which may compensate for one another, can feed the oenocyte pool of LCFAs, suggesting that this step is a critical node for regulating CHC synthesis. Importantly, flies deficient in LCFA synthesis sacrificed their triacylglycerol stores while maintaining some CHC production. Moreover, pheromone production was lower in adult flies that emerged from larvae that were fed excess dietary lipids, and their mating success was lower. Further, we showed that pheromone production in the oenocytes depends on lipid metabolism in the fat tissue and that fatty acid transport protein, a bipartite acyl-CoA synthase (ACS)/FA transporter, likely acts through its ACS domain in the oenocyte pathway of CHC biogenesis. Our study highlights the importance of environmental and physiological inputs in regulating LCFA synthesis to eventually control sexual communication in a polyphagous animal.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.