Trial reportJournal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology2016
Development and validation of a patient-tailored dose regime in myocardial perfusion imaging using conventional SPECT.
Trial report in Journal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
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Who cites it
12 citing papers in PubMed, 36 citations in OpenAlex.
- Quality metrics for single-photon emission computed tomography myocardial perfusion imaging: an ASNC information statement.Journal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology · 2023Review
- Personalization ofEJNMMI physics · 2023Article
- An Algorithm for Individual Dosage in Cadmium-Zinc-Telluride SPECT-Gated Radionuclide Angiography.Diagnostics (Basel, Switzerland) · 2021Article
- Body weight-dependent Rubidium-82 activity results in constant image quality in myocardial perfusion imaging with PET.Journal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology · 2021Article
- Retrospective fractional dose reduction in Tc-99m cardiac perfusion SPECT/CT patients: A human and model observer study.Journal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology · 2021Article
- Patient-specific SPECT imaging protocols to standardize image noise.Journal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology · 2021Article
- Single Photon Emission Computed Tomography (SPECT) Myocardial Perfusion Imaging Guidelines: Instrumentation, Acquisition, Processing, and Interpretation.Journal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology · 2018Review
- Effect of a patient-specific minimum activity in stress myocardial perfusion imaging using CZT-SPECT: Prognostic value, radiation dose, and scan outcome.Journal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology · 2018Article
- The very hungry caterpillar and the ongoing effort to reduce radiation in myocardial perfusion scintigraphy: Have we become the beautiful butterfly?Journal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology · 2018Article
- Patient-specific activity or scan-time in SPECT myocardial perfusion imaging: A hands-on approach.Journal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology · 2017Article
- Review of cardiovascular imaging in the journal of nuclear cardiology in 2016: Part 2 of 2-myocardial perfusion imaging.Journal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology · 2017Review
- Patient-specific tracer activity in MPI SPECT: A hands-on approach.Journal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology · 2016Article
Corrections and comments
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Authors and funding
9 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundThe decreasing image quality in heavier patients can be compensated by administration of a patient-specific dose in myocardial perfusion imaging (MPI) using a cadmium zinc telluride-based SPECT camera. Our aim was to determine if the same can be achieved when using a conventional SPECT camera.
methods148 patients underwent SPECT stress MPI using a fixed Tc-99m tetrofosmin tracer dose. Measured photon counts were normalized to administered tracer dose and scan time and were correlated with body weight, body mass index, and mass per length to find the best predicting parameter. From these data, a protocol to provide constant image quality was derived, and subsequently validated in 125 new patients.
resultsBody weight was found to be the best predicting parameter for image quality and was used to derive a new dose formula; A admin (MBq) = 223·body weight (kg)(0.65)/T scan (min). The measured photon counts decreased in heavier patients when using a fixed dose (P < .01) but this was no longer observed after applying a body-weight-dependent protocol (P = .20).
conclusionsApplication of a patient-specific protocol resulted in an image quality less depending on patient's weight. The results are most likely independent of the type of SPECT camera used, and, hence, adoption of patient-specific dose and scan time protocols is recommended.
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