ArticleJournal of neuropathology and experimental neurology2015
Primary Meningeal Pleomorphic Xanthoastrocytoma With Anaplastic Features: A Report of 2 Cases, One With BRAF(V600E) Mutation and Clinical Response to the BRAF Inhibitor Dabrafenib.
Article in Journal of neuropathology and experimental neurology, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
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Who cites it
23 citing papers in PubMed, 40 citations in OpenAlex.
- Leptomeningeal Dissemination in TERT Promoter-mutant Anaplastic Pleomorphic Xanthoastrocytoma Responding to BRAF-MEK Inhibition: A Case Report.NMC case report journal · 2026Article
- A clinically annotated transcriptomic atlas of nervous system tumors.Neuro-oncology · 2025Article
- Successful treatment of pediatric patients with high-grade gliomas featuring leptomeningeal metastases by targeting BRAF V600E mutations with dabrafenib plus trametinib: two illustrative cases.International cancer conference journal · 2024Article
- Extra-axial primary meningeal pleomorphic xanthoastrocytoma: a case report.The Pan African medical journal · 2024Article
- Clinical features and surgical outcomes of high grade pleomorphic xanthoastrocytomas: a single-center experience with a systematic review.Frontiers in oncology · 2023Article
- Pleomorphic Xanthoastrocytoma: a single institution retrospective analysis and a review of the literature.La Radiologia medica · 2022Review
- Review
- Review
- Using personalized medicine in gliomas: a genomic approach to diagnosis and overcoming treatment resistance in a case with pleomorphic xanthoastrocytoma.Journal of neurology · 2020Article
- Meningioma: A Review of Clinicopathological and Molecular Aspects.Frontiers in oncology · 2020Review
- Review
- Demography, Pattern of Care, and Survival in Patients with Xanthoastrocytoma: A Systematic Review and Individual Patient Data Analysis of 325 Cases.Journal of neurosciences in rural practice · 2019Article
- Clinico-Histomorphological and Immunohistochemical Profile of Anaplastic Pleomorphic Xanthoastrocytoma: Report of Five Cases and Review of Literature.International journal of hematology-oncology and stem cell research · 2018Article
- BRAF inhibition with concomitant tumor treating fields for a multiply progressive pleomorphic xanthoastrocytoma.CNS oncology · 2018Article
- Dabrafenib in patients with recurrent, BRAF V600E mutated malignant glioma and leptomeningeal disease.Oncology reports · 2017Article
- Dabrafenib and trametinib in BRAFV600E mutated glioma.CNS oncology · 2017Article
- Article
- New Molecular Considerations for Glioma: IDH, ATRX, BRAF, TERT, H3 K27M.Current neurology and neuroscience reports · 2017Review
- Morphological and molecular features of astroblastoma, including BRAFV600E mutations, suggest an ontological relationship to other cortical-based gliomas of children and young adults.Neuro-oncology · 2017Article
- Dabrafenib in BRAFV600-mutated anaplastic pleomorphic xanthoastrocytoma.CNS oncology · 2017Article
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Authors and funding
11 authors at 3 institutions in 1 country.
Funding
Abstract
Primary meningeal gliomas are rare tumors composed of a heterogeneous group of neoplasms. We present 2 clinically aggressive cases of primary meningeal pleomorphic xanthoastrocytoma that clinically mimicked meningioma. One case presented in the posterior fossa of a 56-year-old woman; the other centered on the left operculum of a 35-year-old woman. These cases showed many of the classic features of pleomorphic xanthoastrocytoma, except that xanthomatous cells were rare and eosinophilic granular bodies were inconspicuous. Both cases exhibited high proliferative indices and superficially invaded the brain. One case harboring a BRAF mutation disseminated to the thecal sac and showed a clinical response to the targeted BRAF inhibitor dabrafenib. These cases seem to represent an unusual primarily extra-axial presentation of pleomorphic xanthoastrocytoma and may account for at least some of the previously reported cases of primary meningeal glioma and/or glial fibrillary acidic protein-immunoreactive meningioma variants. We suggest that BRAF mutation analysis be considered in all meningeal lesions showing atypical histologic or immunohistochemical profiles, particularly those exhibiting glial differentiation, as a diagnostic aid and possible indication for targeted therapy.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.