SynthesisThe Clinical journal of pain2015
Interventions for Individuals With High Levels of Needle Fear: Systematic Review of Randomized Controlled Trials and Quasi-Randomized Controlled Trials.
Synthesis in The Clinical journal of pain, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 43 papers, 6 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
43 citing papers in PubMed, 6 syntheses or guidelines pooled it, 88 citations in OpenAlex.
- Intervention Effect of Child Life Specialists on Paediatric Patients: A Systematic Review of Randomized Controlled Trials.Child: care, health and development · 2026Pooled it
- Humanization interventions in general pediatric wards: a systematic review.European journal of pediatrics · 2019Pooled it
- Psychological interventions for needle-related procedural pain and distress in children and adolescents.The Cochrane database of systematic reviews · 2018Pooled it
- Psychological Interventions for Vaccine Injections in Children and Adolescents: Systematic Review of Randomized and Quasi-Randomized Controlled Trials.The Clinical journal of pain · 2015Pooled it
- Simple Psychological Interventions for Reducing Pain From Common Needle Procedures in Adults: Systematic Review of Randomized and Quasi-Randomized Controlled Trials.The Clinical journal of pain · 2015Pooled it
- Procedural and Physical Interventions for Vaccine Injections: Systematic Review of Randomized Controlled Trials and Quasi-Randomized Controlled Trials.The Clinical journal of pain · 2015Pooled it
- Comparative evaluation of the effectiveness of transcutaneous electric nerve stimulation and photobiostimulation using diode laser prior to local anesthesia administration in children undergoing bilateral orthodontic extraction- a randomized controlled clinical trial.Lasers in medical science · 2025Trial
- Comparative efficacy of pharmacological and non-pharmacological interventions for mitigating pain and anxiety associated with venipuncture: a randomised controlled trial.BMJ paediatrics open · 2024Trial
- Comparative evaluation of pain perception with a new needle-free system and dental needle method in children: a randomized clinical trial.BMC anesthesiology · 2021Trial
- Trauma-Informed Care Approach During Pediatric Venipuncture: Pre-Post Associations with Fear and Heart Rate.Children (Basel, Switzerland) · 2026Article
- Coping with Pokes: Child, Caregiver, and Clinician Feedback on a Caregiver-Led Educational Resource for Managing Children's Needle Fear.Nursing reports (Pavia, Italy) · 2026Article
- Factors associated with documented distress during venipuncture in routine health checkups.Frontiers in psychiatry · 2026Article
- Pain disparities attributed to linguistic minoritization in health care settings.The journal of pain · 2025Review
- Effect of low-level laser therapy on pain perception and anxiety levels in conventional local anesthesia injection.Journal of dental anesthesia and pain medicine · 2025Article
- Advancing the treatment of anxiety disorders in transition-age youth: a review of the therapeutic effects of unconscious exposure.Journal of child psychology and psychiatry, and allied disciplines · 2025Review
- Observational Behavioral Coding in the Pediatric Emergency Department: Development of the Emergency Department Child Behavior Coding System.The Journal of emergency medicine · 2024Article
- Prevalence, factors associated and management of needle phobia among the general population in Saudi Arabia and Egypt.BMC psychiatry · 2024Article
- Using Non-Violent Discipline Tools: Evidence Suggesting the Importance of Attunement.International journal of environmental research and public health · 2023Review
- An Exposure-Based Video Game (Dr. Zoo) to Reduce Needle Phobia in Children Aged 3 to 6 Years: Development and Mixed Methods Pilot Study.JMIR serious games · 2023Article
- Picturing Bravery: A Rapid Review of Needle Procedures Depicted in Children's Picture Books.Children (Basel, Switzerland) · 2023Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
9 authors at 6 institutions in 2 countries.
Funding
Abstract
backgroundThis systematic review evaluated the effectiveness of exposure-based psychological and physical interventions for the management of high levels of needle fear and/or phobia and fainting in children and adults. DESIGN/
methodsA systematic review identified relevant randomized and quasi-randomized controlled trials of children, adults, or both with high levels of needle fear, including phobia (if not available, then populations with other specific phobias were included). Critically important outcomes were self-reported fear specific to the feared situation and stimulus (psychological interventions) or fainting (applied muscle tension). Data were pooled using standardized mean difference (SMD) or relative risk with 95% confidence intervals.
resultsThe systematic review included 11 trials. In vivo exposure-based therapy for children 7 years and above showed benefit on specific fear (n=234; SMD: -1.71 [95% CI: -2.72, -0.7]). In vivo exposure-based therapy with adults reduced fear of needles posttreatment (n=20; SMD: -1.09 [-2.04, -0.14]) but not at 1-year follow-up (n=20; SMD: -0.28 [-1.16, 0.6]). Compared with single session, a benefit was observed for multiple sessions of exposure-based therapy posttreatment (n=93; SMD: -0.66 [-1.08, -0.24]) but not after 1 year (n=83; SMD: -0.37 [-0.87, 0.13]). Non in vivo e.g., imaginal exposure-based therapy in children reduced specific fear posttreatment (n=41; SMD: -0.88 [-1.7, -0.05]) and at 3 months (n=24; SMD: -0.89 [-1.73, -0.04]). Non in vivo exposure-based therapy for adults showed benefit on specific fear (n=68; SMD: -0.62 [-1.11, -0.14]) but not procedural fear (n=17; SMD: 0.18 [-0.87, 1.23]). Applied tension showed benefit on fainting posttreatment (n=20; SMD: -1.16 [-2.12, -0.19]) and after 1 year (n=20; SMD: -0.97 [-1.91, -0.03]) compared with exposure alone.
conclusionsExposure-based psychological interventions and applied muscle tension show evidence of benefit in the reduction of fear in pediatric and adult populations.
Indexed as
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.