ReviewPloS one2015
Understanding the Impact of Brain Disorders: Towards a 'Horizontal Epidemiology' of Psychosocial Difficulties and Their Determinants.
Review in PloS one, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers, 3 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
21 citing papers in PubMed, 3 syntheses or guidelines pooled it, 63 citations in OpenAlex.
- Risk factors associated to disability in primary headaches: a systematic review to inform future iterations of the Global Burden of Disease Study.The journal of headache and pain · 2025Pooled it
- Psychosocial wellbeing of people with dementia: systematic review and construct analysis.Acta neuropsychiatrica · 2025Pooled it
- Barriers and Facilitation Measures Related to People With Mental Disorders When Using the Web: A Systematic Review.Journal of medical Internet research · 2016Pooled it
- Trial
- Development of the Migraine-Related Stigma (MiRS) Questionnaire: Results of the OVERCOME (US) Study.Headache · 2025Observational
- Cognitive behavioral interventions for depression and anxiety in adults with neurological disorders: a systematic review and meta-analysis.Psychological medicine · 2024Review
- Relationship Between Spirituality, Religiosity, and General Life Satisfaction Among Canadians Living with Neurological Conditions in New Brunswick and Manitoba.Journal of religion and health · 2022Article
- Validation of PARADISE 24 and Development of PARADISE-EDEN 36 in Patients with Dementia.International journal of environmental research and public health · 2022Article
- The development of a Self-Rated ICF-based questionnaire (HEAR-COMMAND Tool) to evaluate Hearing, Communication, and Conversation disability: Multinational experts' and patients' perspectives.Frontiers in rehabilitation sciences · 2022Article
- Determinants of Self-Stigma in People with Parkinson's Disease: A Mixed Methods Scoping Review.Journal of Parkinson's disease · 2022Article
- How to capture the individual and societal impacts of syndemics: the lived experience of COVID-19.BMJ global health · 2021Article
- Psychosocial difficulties and treatment retention in inpatient detoxification programmes.Nordisk alkohol- & narkotikatidskrift : NAT · 2021Article
- Psychometric Properties of the Persian Version of the PARADISE-24 Questionnaire.International journal of preventive medicine · 2021Article
- Difficulties Encountered by People With Depression and Anxiety on the Web: Qualitative Study and Web-Based Expert Survey.Journal of medical Internet research · 2019Article
- Comorbidity and concurrence of problems: Overlooked, not under-researched.Nordisk alkohol- & narkotikatidskrift : NAT · 2019Article
- What makes the difference in people's lives when they have a mental disorder?International journal of public health · 2018Article
- Psychosocial difficulties in patients with episodic migraine: a cross-sectional study.Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology · 2016Article
- Differential protection of black-seed oil on econucleotidase, cholinesterases and aminergic catabolizing enzyme in haloperidol-induced neuronal damage of male rats.Therapeutic advances in drug safety · 2016Article
- Pediatric Autoimmune Disorders Associated with Streptococcal Infections and Tourette's Syndrome in Preclinical Studies.Frontiers in neuroscience · 2016Review
- Determinants of Psychosocial Difficulties Experienced by Persons with Brain Disorders: Towards a 'Horizontal Epidemiology' Approach.PloS one · 2015Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
10 authors at 8 institutions in 8 countries.
Funding
Abstract
objectiveTo test the hypothesis of 'horizontal epidemiology', i.e. that psychosocial difficulties (PSDs), such as sleep disturbances, emotional instability and difficulties in personal interactions, and their environmental determinants are experienced in common across neurological and psychiatric disorders, together called brain disorders. STUDY
designA multi-method study involving systematic literature reviews, content analysis of patient-reported outcomes and outcome instruments, clinical input and a qualitative study was carried out to generate a pool of PSD and environmental determinants relevant for nine different brain disorders, namely epilepsy, migraine, multiple sclerosis, Parkinson's disease, stroke, dementia, depression, schizophrenia and substance dependency. Information from these sources was harmonized and compiled, and after feedback from external experts, a data collection protocol including PSD and determinants common across these nine disorders was developed. This protocol was implemented as an interview in a cross-sectional study including a convenience sample of persons with one of the nine brain disorders. PSDs endorsed by at least 25% of patients with a brain disorder were considered associated with the disorder. PSD were considered common across disorders if associated to 5 out of the 9 brain disorders and if among the 5 both neurological and psychiatric conditions were represented.
settingThe data collection protocol with 64 PSDs and 20 determinants was used to collect data from a convenience sample of 722 persons in four specialized health care facilities in Europe.
results57 of the PSDs and 16 of the determinants included in the protocol were found to be experienced across brain disorders.
conclusionThis is the first evidence that supports the hypothesis of horizontal epidemiology in brain disorders. This result challenges the brain disorder-specific or vertical approach in which clinical and epidemiological research about psychosocial difficulties experienced in daily life is commonly carried in neurology and psychiatry and the way in which the corresponding health care delivery is practiced in many countries of the world.
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Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.