Evidence map›Paper›PMID 26352802›Full record

ArticlePloS one2015

The Impact of Selective Dopamine D2, D3 and D4 Ligands on the Rat Gambling Task.

Patricia Di Ciano, Abhiram Pushparaj, Aaron Kim, Jessica Hatch, Talal Masood, Abby Ramzi, Maram A T M Khaled, Isabelle Boileau, Catherine A Winstanley, Bernard Le Foll

Abstract readComparative Study
PubMed Full text at PMC Publisher
In one paragraph

Article in PloS one, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.

0numbers the graph read from it
0cells of the map it votes in
15citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

15 citing papers in PubMed.

  1. Article
  2. Article
  3. Review
  4. Article
  5. Review
  6. Review
  7. Article
  8. Dopamine and Stress System Modulation of Sex Differences in Decision Making.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2018
    Article
  9. Article
  10. Article
  11. Article
  12. Sex differences in animal models of decision making.Journal of neuroscience research · 2017
    Review
  13. Article
  14. Article
  15. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Patricia Di CianoTranslational Addiction Research Laboratory, Centre for Addiction and Mental Health, University of Toronto, 33 Russell Street, Toronto, Canada M5S 2S1.
Abhiram PushparajTranslational Addiction Research Laboratory, Centre for Addiction and Mental Health, University of Toronto, 33 Russell Street, Toronto, Canada M5S 2S1.
Aaron KimTranslational Addiction Research Laboratory, Centre for Addiction and Mental Health, University of Toronto, 33 Russell Street, Toronto, Canada M5S 2S1.
Jessica HatchDepartment of Pharmacology, University of Toronto, Toronto, ON, Canada.
Talal MasoodTranslational Addiction Research Laboratory, Centre for Addiction and Mental Health, University of Toronto, 33 Russell Street, Toronto, Canada M5S 2S1.
Abby RamziTranslational Addiction Research Laboratory, Centre for Addiction and Mental Health, University of Toronto, 33 Russell Street, Toronto, Canada M5S 2S1.
Maram A T M KhaledTranslational Addiction Research Laboratory, Centre for Addiction and Mental Health, University of Toronto, 33 Russell Street, Toronto, Canada M5S 2S1; Pain Management Unit, Department of Anaesthesia, Medical Research Institute, Alexandria University, Alexandria, Egypt.
Isabelle BoileauAddiction Imaging Research Group, Centre for Addiction and Mental Health, 250 College Street, Toronto, ON, Canada M5T 1R.
Catherine A WinstanleyDepartment of Psychology, University of British Columbia, Vancouver, BC, Canada.
Bernard Le FollTranslational Addiction Research Laboratory, Centre for Addiction and Mental Health, University of Toronto, 33 Russell Street, Toronto, Canada M5S 2S1; Alcohol Research and Treatment Clinic, Addiction Medicine Services, Ambulatory Care and Structured Treatments, Centre for Addiction and Mental Health, Toronto, ON, Canada; Campbell Family Mental Health Research Institute, Centre for Addiction and Mental Health, CAMH, Toronto, ON, Canada; Department of Family and Community Medicine, University of Toronto, Toronto, ON, Canada; Department of Pharmacology, University of Toronto, Toronto, ON, Canada; Department of Psychiatry, Division of Brain and Therapeutics, University of Toronto, Toronto, ON, Canada; Institute of Medical Sciences, University of Toronto, Toronto, ON, Canada.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Gambling is an addictive disorder with serious societal and personal costs. To-date, there are no approved pharmacological treatments for gambling disorder. Evidence suggests a role for dopamine in gambling disorder and thus may provide a therapeutic target. The present study therefore aimed to investigate the effects of selective antagonists and agonists of D2, D3 and D4 receptors in a rodent analogue of the Iowa gambling task used clinically. In this rat gambling task (rGT), animals are trained to associate different response holes with different magnitudes and probabilities of food pellet rewards and punishing time-out periods. As in the Iowa gambling task, the optimal strategy is to avoid the tempting high-risk high-reward options, and instead favor those linked to smaller per-trial rewards but also lower punishments, thereby maximizing the amount of reward earned over time. Administration of those selective ligands did not affect decision making under the rGT. Only the D4 drug had modest effects on latency measures suggesting that D4 may contribute in some ways to decision making under this task.

Indexed as

GamblingGames, ExperimentalAnimalsConditioning, OperantDecision MakingDopamine AgentsDopamine AntagonistsDopamine D2 Receptor AntagonistsLigandsMalePunishmentRatsRats, Long-EvansReaction TimeReceptors, Dopamine D2Receptors, Dopamine D3Dopamine AgentsDopamine AntagonistsDopamine D2 Receptor AntagonistsLigandsReceptors, Dopamine D2Receptors, Dopamine D3Receptors, Dopamine D4

Identifiers

PMID26352802
PMCPMC4564230

What OpenQuestion holds

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LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.