Evidence map›Paper›PMID 26352642›Full record

ArticleHormone research in paediatrics2015

In Nonobese Girls, Waist Circumference as a Predictor of Insulin Resistance Is Comparable to MRI Fat Measures and Superior to BMI.

Peter M Wolfgram, Ellen L Connor, Jennifer L Rehm, Jens C Eickhoff, Wei Zha, Scott B Reeder, David B Allen

Abstract read
In one paragraph

Article in Hormone research in paediatrics, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Peter M WolfgramPediatrics, Medical College of Wisconsin, Milwaukee, Wis., USA.
Ellen L Connor
Jennifer L Rehm
Jens C Eickhoff
Wei Zha
Scott B Reeder
David B Allen

Funding

Technical Validation of MRI Biomarkers of Liver FatR01DK088925 · NIDDK · UNIVERSITY OF WISCONSIN-MADISON · PI REEDER, SCOTT B., SIRLIN, CLAUDE B · 2010 to 2021
$7.1M
Childhood Diabetes Clinical & Molecular Research Training ProgramT32DK077586 · NIDDK · UNIVERSITY OF WISCONSIN-MADISON · PI Brigid Ellen Gregg, Scott B. Reeder · 2008 to 2026
$2.4M
Technical Development of Quantitative Biomarkers of Fatty Liver Disease with MRIR01DK083380 · NIDDK · UNIVERSITY OF WISCONSIN-MADISON · PI REEDER, SCOTT B. · 2010 to 2013
$1.2M
Volumetric Perfusion MRI of Liver Tumors to Detect Early Response to ChemotherapyRC1EB010384 · NIBIB · UNIVERSITY OF WISCONSIN-MADISON · PI REEDER, SCOTT B. · 2009 to 2010
$973k
Evolution of Quantitative MRI Biomarkers of Metabolic Syndrome During PubertyK24DK102595 · NIDDK · UNIVERSITY OF WISCONSIN-MADISON · PI REEDER, SCOTT B. · 2014 to 2018
$927k
NIBIB NIH HHS RC1 EB010384NIBIB NIH HHS RC1EB010384NIDDK NIH HHS K24 DK102595NIDDK NIH HHS R01 DK083380NIDDK NIH HHS R01DK083380NIDDK NIH HHS R01 DK088925NIDDK NIH HHS R01DK088925NIDDK NIH HHS T32 DK077586NIDDK NIH HHS T32DK07758604
6 · The paper itself

Abstract

objectiveThe aim of this study was to investigate the degree to which waist circumference (WC), body mass index (BMI), and magnetic resonance imaging (MRI)-measured abdominal fat deposition predict insulin resistance (IR) in nonobese girls of diverse racial and ethnic backgrounds.

methodsFifty-seven nonobese girls (12 African-American, 16 Hispanic White, and 29 non-Hispanic White girls) aged 11-14 years were assessed for WC, MRI hepatic proton density fat fraction, visceral and subcutaneous adipose tissue volume, BMI Z-score, fasting insulin, homeostasis model of assessment (HOMA)-IR, adiponectin, leptin, sex hormone-binding globulin, high-density lipoprotein cholesterol, and triglycerides.

resultsUnivariate and multivariate analyses adjusted for race and ethnicity indicated that only WC and visceral adipose tissue volume were independent predictors of fasting insulin and HOMA-IR, while hepatic proton density fat fraction, BMI Z-score, and subcutaneous adipose tissue volume were dependent predictors. Hispanic White girls showed significantly higher mean fasting insulin and HOMA-IR and lower sex hormone-binding globulin than non-Hispanic White girls (p < 0.01).

conclusionsIn nonobese girls of diverse racial and ethnic backgrounds, WC, particularly when adjusted for race or ethnicity, is an independent predictor of IR comparable to MRI-derived measurements of fat and superior to the BMI Z-score.

Indexed as

AdiponectinAdipose TissueAdolescentBlood GlucoseBody Mass IndexChildFemaleHumansInsulinInsulin ResistanceLeptinMagnetic Resonance ImagingSex Hormone-Binding GlobulinTriglyceridesWaist CircumferenceAdiponectinADIPOQ protein, humanBlood GlucoseInsulinLeptinSex Hormone-Binding GlobulinTriglycerides

Identifiers

PMID26352642
PMCPMC4644098

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.