Evidence map›Paper›PMID 26352574›Full record

ArticlePloS one2015

Age- and Gender-related Disparities in Primary Percutaneous Coronary Interventions for Acute ST-segment elevation Myocardial Infarction.

Thomas Pilgrim, Dik Heg, Kali Tal, Paul Erne, Dragana Radovanovic, Stephan Windecker, Peter Jüni, AMIS Plus Investigators

Abstract read
In one paragraph

Article in PloS one, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed.

  1. Trial
  2. External validity of the "all-comers" design: insights from the BIOSCIENCE trial.Clinical research in cardiology : official journal of the German Cardiac Society · 2016
    Trial
  3. Gender-based differences among ST-elevation myocardial infarction patients in Egypt: secondary analysis from the ACCA-EAPCI ESC-STEMI registry.The Egyptian heart journal : (EHJ) : official bulletin of the Egyptian Society of Cardiology · 2025
    Article
  4. Article
  5. Article
  6. Contemporary Revascularization Dilemmas in Older Adults.Journal of the American Heart Association · 2020
    Review
  7. Article
  8. Article
  9. Article
  10. Observational
  11. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Thomas PilgrimDepartment of Cardiology, Swiss Cardiovascular Center, Bern University Hospital, Bern, Switzerland.
Dik HegInstitute of Social and Preventive Medicine (ISPM) and Clinical Trials Unit, Department of Clinical Research, University of Bern, Bern, Switzerland, Switzerland.
Kali TalInstitute of Social and Preventive Medicine (ISPM) and Clinical Trials Unit, Department of Clinical Research, University of Bern, Bern, Switzerland, Switzerland.
Paul ErneDivision of Cardiology, St. Anna Hospital, Lucerne, Switzerland.
Dragana RadovanovicAMIS Plus Data Center, Institute for Social and Preventive Medicine, University of Zurich, Zurich, Switzerland.
Stephan WindeckerDepartment of Cardiology, Swiss Cardiovascular Center, Bern University Hospital, Bern, Switzerland.
Peter JüniInstitute Primary Care and Clinical Epidemiology, University of Bern, Bern, Switzerland.
AMIS Plus Investigators

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundPrevious analyses reported age- and gender-related differences in the provision of cardiac care. The objective of the study was to compare circadian disparities in the delivery of primary percutaneous coronary intervention (PCI) for acute myocardial infarction (AMI) according to the patient's age and gender.

methodsWe investigated patients included into the Acute Myocardial Infarction in Switzerland (AMIS) registry presenting to one of 11 centers in Switzerland providing primary PCI around the clock, and stratified patients according to gender and age.

findingsA total of 4723 patients presented with AMI between 2005 and 2010; 1319 (28%) were women and 2172 (54%) were ≥65 years of age. More than 90% of patients <65 years of age underwent primary PCI without differences between gender. Elderly patients and particularly women were at increased risk of being withheld primary PCI (males adj. HR 4.91, 95% CI 3.93-6.13; females adj. HR 9.31, 95% CI 7.37-11.75) as compared to males <65 years of age. An increased risk of a delay in door-to-balloon time >90 minutes was found in elderly males (adj HR 1.66 (95% CI 1.40-1.95), p<0.001) and females (adj HR 1.57 (95% CI 1.27-1.93), p<0.001), as well as in females <65 years (adj HR 1.47 (95% CI 1.13-1.91), p = 0.004) as compared to males <65 years of age, with significant differences in circadian patterns during on- and off-duty hours.

conclusionsIn a cohort of patients with AMI in Switzerland, we observed discrimination of elderly patients and females in the circadian provision of primary PCI.

Indexed as

GeriatricsPercutaneous Coronary InterventionSex CharacteristicsAgedAged, 80 and overAge FactorsAspirinClopidogrelFemaleHospitalsHumansMaleMiddle AgedMyocardial InfarctionSwitzerlandTiclopidineAspirinClopidogrelTiclopidine

Identifiers

PMID26352574
PMCPMC4564139

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.