ArticleJournal of cognitive neuroscience2015
Shared and Distinct Neuroanatomic Regions Critical for Tool-related Action Production and Recognition: Evidence from 131 Left-hemisphere Stroke Patients.
Article in Journal of cognitive neuroscience, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 46 papers, 1 of them a synthesis that pooled it.
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Who cites it
46 citing papers in PubMed, 1 synthesis or guideline pooled it, 106 citations in OpenAlex.
- Taxonomic and thematic semantic systems.Psychological bulletin · 2017Pooled it
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- Object-directed action representations are componentially built in parietal cortex.Proceedings of the National Academy of Sciences of the United States of America · 2025Article
- Neurocognitive mechanisms underlying action tool knowledge tasks: specificity of tool-tool compared to hand-tool compatibility tasks.Communications biology · 2025Article
- Cognitive neuropsychological and neuroanatomic predictors of naturalistic action performance in left hemisphere stroke: A retrospective analysis.Cortex; a journal devoted to the study of the nervous system and behavior · 2025Article
- Cognitive neuropsychological and neuroanatomic predictors of naturalistic action performance in left hemisphere stroke: a retrospective analysis.bioRxiv : the preprint server for biology · 2025Article
- Right hemisphere stroke is linked to reduced social connectedness in the UK Biobank cohort.Scientific reports · 2024Article
- Reciprocal interactions among parietal and occipito-temporal representations support everyday object-directed actions.Neuropsychologia · 2024Article
- Gesture profiles distinguish primary progressive aphasia variants: A preliminary study.Aphasiology · 2024Article
- Mechanisms and neuroanatomy of response selection in tool and non-tool action tasks: Evidence from left-hemisphere stroke.Cortex; a journal devoted to the study of the nervous system and behavior · 2023Article
- Shared and distinct routes in speech and gesture imitation: Evidence from stroke.Cortex; a journal devoted to the study of the nervous system and behavior · 2023Article
- Novel objects with causal event schemas elicit selective responses in tool- and hand-selective lateral occipitotemporal cortex.Cerebral cortex (New York, N.Y. : 1991) · 2023Article
- Gesture profiles distinguish primary progressive aphasia variants.bioRxiv : the preprint server for biology · 2023Article
- Brain intrinsic connection patterns underlying tool processing in human adults are present in neonates and not in macaques.NeuroImage · 2022Article
- Proprioception-based movement goals support imitation and are disrupted in apraxia.Cortex; a journal devoted to the study of the nervous system and behavior · 2022Article
- What Happened to Mirror Neurons?Perspectives on psychological science : a journal of the Association for Psychological Science · 2022Article
- Treating limb apraxia via action semantics: a preliminary study.Neuropsychological rehabilitation · 2021Article
- Pantomime of tool use: looking beyond apraxia.Brain communications · 2021Review
- Multimodal comprehension in left hemisphere stroke patients.Cortex; a journal devoted to the study of the nervous system and behavior · 2020Article
Corrections and comments
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Authors and funding
3 authors at 2 institutions in 1 country.
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Abstract
The inferior frontal gyrus and inferior parietal lobe have been characterized as human homologues of the monkey "mirror neuron" system, critical for both action production (AP) and action recognition (AR). However, data from brain lesion patients with selective impairment on only one of these tasks provide evidence of neural and cognitive dissociations. We sought to clarify the relationship between AP and AR, and their critical neural substrates, by directly comparing performance of 131 chronic left-hemisphere stroke patients on both tasks--to our knowledge, the largest lesion-based experimental investigation of action cognition to date. Using voxel-based lesion-symptom mapping, we found that lesions to primary motor and somatosensory cortices and inferior parietal lobule were associated with disproportionately impaired performance on AP, whereas lesions to lateral temporo-occipital cortex were associated with a relatively rare pattern of disproportionately impaired performance on AR. In contrast, damage to posterior middle temporal gyrus was associated with impairment on both AP and AR. The distinction between lateral temporo-occipital cortex, critical for recognition, and posterior middle temporal gyrus, important for both tasks, suggests a rough gradient from modality-specific to abstract representations in posterior temporal cortex, the first lesion-based evidence for this phenomenon. Overall, the results of this large patient study help to bring closure to a long-standing debate by showing that tool-related AP and AR critically depend on both common and distinct left hemisphere neural substrates, most of which are external to putative human mirror regions.
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