Evidence map›Paper›PMID 26351754›Full record

ArticleMuscle & nerve2016

Respiratory motor function in individuals with centronuclear myopathies.

Barbara K Smith, Markus S Renno, Meghan M Green, Terry M Sexton, Lee Ann Lawson, Anatole D Martin, Manuela Corti, Barry J Byrne

Erratum issuedAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Muscle & nerve, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.7field-weighted citation impact, top 33% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 8 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

8 authors at 3 institutions in 1 country.

Barbara K SmithDepartment of Physical Therapy, University of Florida, P.O. Box 100154, Gainesville, Florida, 32610-0154, USA.
Markus S RennoDepartment of Pediatrics, Vanderbilt University, Nashville, Tennessee, USA.
Meghan M GreenCollege of Medicine, University of Kentucky, Lexington, Kentucky, USA.
Terry M SextonDepartment of Pediatrics, University of Florida, Gainesville, Florida, USA.
Lee Ann LawsonDepartment of Pediatrics, University of Florida, Gainesville, Florida, USA.
Anatole D MartinDepartment of Physical Therapy, University of Florida, P.O. Box 100154, Gainesville, Florida, 32610-0154, USA.
Manuela CortiDepartment of Pediatrics, University of Florida, Gainesville, Florida, USA.
Barry J ByrneDepartment of Pediatrics, University of Florida, Gainesville, Florida, USA.
University of Florida · USUniversity of Kentucky · USVanderbilt University · US

Funding

Using social networks to map and evaluate team science across CTSA hubsUL1TR001427 · NCATS · UNIVERSITY OF FLORIDA · PI MITCHELL, DUANE A. · 2015 to 2024
$37.2M
Rehabilitation Research Career Development ProgramK12HD055929 · NICHD · UNIVERSITY OF TEXAS MED BR GALVESTON · PI BROWN, DAVID A · 2007 to 2021
$11.7M
Developmental Determinants of Cardiovascular DiseaseT32HL105334 · NHLBI · VANDERBILT UNIVERSITY MEDICAL CENTER · PI BALDWIN, H SCOTT · 2011 to 2021
$4.3M
NCATS NIH HHS UL1 TR001427NHLBI NIH HHS T32 HL105334NICHD NIH HHS K12 HD055929NICHD NIH HHS K12HD055929
6 · The paper itself

Abstract

unlabelledI NTRODUCTION: Individuals with X-linked myotubular myopathy (XLMTM) and other centronuclear myopathies (CNMs) frequently have profound respiratory insufficiency that requires support early in life. Still, few quantitative data exist to characterize respiratory motor function in CNM.

methodsWe evaluated the reliance upon mechanical ventilation (MV), ventilatory kinematics, unassisted tidal volumes, and maximal respiratory pressures in 14 individuals with CNMs, including 10 boys with XLMTM.

resultsThirteen participants required full-time, invasive MV. Maximal inspiratory pressures were higher in subjects who breathed unsupported at least 1 hour/day as compared with 24-hour MV users [33.7 (11.9-42.3) vs. 8.4 (6.0-10.9) cm H(2)O, P < 0.05]. Years of MV dependence correlated significantly with MEP (r = -0.715, P < 0.01).

conclusionsRespiratory function in CNMs may be related to deconditioning from prolonged MV and/or differences in residual respiratory muscle strength. Results from this study may assist in evaluating severe respiratory insufficiency in neuromuscular clinical care and research.

Indexed as

AdolescentAdultAgedChildChild, PreschoolFemaleHumansInfantMaleMiddle AgedMyopathies, Structural, CongenitalPressureRespiration, ArtificialRespiration DisordersRespiratory Function TestsRespiratory Musclescentronuclear myopathyclinical trial designmechanical ventilationmyotubular myopathyrespiratory function

Identifiers

PMID26351754
PMCPMC4718843
OpenAlexW2126539027

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.