ArticleProceedings of the National Academy of Sciences of the United States of America2015
Dissecting repulsion linkage in the dwarfing gene Dw3 region for sorghum plant height provides insights into heterosis.
Article in Proceedings of the National Academy of Sciences of the United States of America, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 77 papers, 1 of them a synthesis that pooled it.
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Who cites it
77 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Meta-analysis identifies pleiotropic loci controlling phenotypic trade-offs in sorghum.Genetics · 2021Pooled it
- Multi-Omics Integration Drives Precision Breeding in Sorghum: Molecular Dissection and Breeding Practice.Plants (Basel, Switzerland) · 2026Review
- Genomic constraint and hypervariability correlate with fitness effects in elite tetraploid potato breeding material.PLoS genetics · 2026Article
- Hybrid sorghum breeding in China: A historical review and perspectives.Journal of integrative plant biology · 2026Review
- Persistent and transient QTLs underlying growth trajectory of plant height in sorghum.Journal of experimental botany · 2026Article
- Toward Breeding by Gene Design: Constructing the Ideotype ofPlants (Basel, Switzerland) · 2026Review
- Additive and Partially Dominant Effects from Genomic Variation Contribute to Rice Heterosis.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026Article
- Integrating Multi-omics Analysis to Decipher the Genetic Basis of Heterosis in Xieyou9308.Rice (New York, N.Y.) · 2025Article
- Six-gene model underlying heterosis for culm length and flowering date in sorghum (Sorghum bicolor (L.) Moench).Scientific reports · 2025Article
- DNA methylation in plant heterosis: mechanisms and prospects.Functional & integrative genomics · 2025Review
- QTL mapping and candidate genes prediction for plant height and brix content in sorghum [Sorghum bicolor (L.) Moench].TAG. Theoretical and applied genetics. Theoretische und angewandte Genetik · 2025Article
- Genetic mapping and isolation of Rht28, a locus on wheat chromosome arm 2AL affecting plant height, grain size, and grain weight.TAG. Theoretical and applied genetics. Theoretische und angewandte Genetik · 2025Article
- The origin and evolution of cultivated rice and genomic signatures of heterosis for yield traits in super-hybrid rice.BMC biology · 2025Article
- Unveiling shared genetic regulators of plant architectural and biomass yield traits in the Sorghum Association Panel.Journal of experimental botany · 2025Article
- Genetic and Environmental Patterns Underlying Phenotypic Plasticity in Flowering Time and Plant Height in Sorghum.Plant, cell & environment · 2025Article
- Polymerization of beneficial plant height QTLs to develop superior lines which can achieving hybrid performance levels.Molecular breeding : new strategies in plant improvement · 2025Article
- A MYB transcription factor underlying plant height in sorghum qHT7.1 and maize Brachytic 1 loci.The Plant journal : for cell and molecular biology · 2024Article
- Molecular Mechanisms of Heterosis and Its Applications in Tree Breeding: Progress and Perspectives.International journal of molecular sciences · 2024Review
- Novel Allelic Mutations inInternational journal of molecular sciences · 2024Article
- Review
17 more citing papers are in PubMed but not listed here.
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5 authors.
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Abstract
Heterosis is a main contributor to yield increase in many crop species. Different mechanisms have been proposed for heterosis: dominance, overdominance, epistasis, epigenetics, and protein metabolite changes. However, only limited examples of molecular dissection and validation of these mechanisms are available. Here, we present an example of discovery and validation of heterosis generated by a combination of repulsion linkage and dominance. Using a recombinant inbred line population, a separate quantitative trait locus (QTL) for plant height (qHT7.1) was identified near the genomic region harboring the known auxin transporter Dw3 gene. With two loci having repulsion linkage between two inbreds, heterosis in the hybrid can appear as a single locus with an overdominance mode of inheritance (i.e., pseudo-overdominance). Individually, alleles conferring taller plant height exhibited complete dominance over alleles conferring shorter height. Detailed analyses of different height components demonstrated that qHT7.1 affects both the upper and lower parts of the plant, whereas Dw3 affects only the part below the flag leaf. Computer simulations show that repulsion linkage could influence QTL detection and estimation of effect in segregating populations. Guided by findings in linkage mapping, a genome-wide association study of plant height with a sorghum diversity panel pinpointed genomic regions underlying the trait variation, including Dw1, Dw2, Dw3, Dw4, and qHT7.1. Multilocus mixed model analysis confirmed the advantage of complex trait dissection using an integrated approach. Besides identifying a specific genetic example of heterosis, our research indicated that integrated molecular dissection of complex traits in different population types can enable plant breeders to fine tune the breeding process for crop production.
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