ArticleJournal of pregnancy2015
Impaired Fertility Associated with Subclinical Hypothyroidism and Thyroid Autoimmunity: The Danish General Suburban Population Study.
Article in Journal of pregnancy, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 15 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
15 citing papers in PubMed, 83 citations in OpenAlex.
- Causal association between thyroid function and the risk of infertility: a Mendelian randomization study.Frontiers in endocrinology · 2024Article
- The Role of Thyroid Hormones, Vitamins, and Microelements in Female Infertility.Revista brasileira de ginecologia e obstetricia : revista da Federacao Brasileira das Sociedades de Ginecologia e Obstetricia · 2023Article
- Association of Preconception Thyrotropin Levels With Fecundability and Risk of Spontaneous Abortion in China.JAMA network open · 2022Article
- The association between subclinical hypothyroidism and TPOAb positivity with infertility in a population-based study: Tehran thyroid study (TTS).BMC endocrine disorders · 2021Article
- Effect of the Cut-Off Level for Thyroid-Stimulating Hormone on the Prevalence of Subclinical Hypothyroidism among Infertile Mexican Women.Diagnostics (Basel, Switzerland) · 2021Article
- 2021 European Thyroid Association Guideline on Thyroid Disorders prior to and during Assisted Reproduction.European thyroid journal · 2021Article
- Phosphodiesterase 8B Polymorphism rs4704397 Is Associated with Infertility in Subclinical Hypothyroid Females: A Case-Control Study.International journal of fertility & sterility · 2020Article
- The chance of a live birth after assisted reproduction in women with thyroid disorders.Clinical epidemiology · 2019Article
- High Thyroid Stimulating Hormone Level Is Associated With Hyperandrogenism in Euthyroid Polycystic Ovary Syndrome (PCOS) Women, Independent of Age, BMI, and Thyroid Autoimmunity: A Cross-Sectional Analysis.Frontiers in endocrinology · 2019Article
- The Impact of Subclinical Hypothyroidism on Adverse Perinatal Outcomes and the Role of Thyroid Screening in Pregnancy.Frontiers in endocrinology · 2019Article
- An exploration on the influence of positive simple thyroid peroxidase antibody on female infertility.Experimental and therapeutic medicine · 2018Article
- Subclinical Hypothyroidism in Women Planning Conception and During Pregnancy: Who Should Be Treated and How?Journal of the Endocrine Society · 2018Review
- Higher TSH Levels Within the Normal Range Are Associated With Unexplained Infertility.The Journal of clinical endocrinology and metabolism · 2018Article
- Corrigendum to "Impaired Fertility Associated with Subclinical Hypothyroidism and Thyroid Autoimmunity: The Danish General Suburban Population Study".Journal of pregnancy · 2017Article
- Consequences of hyperthyroidism in male and female fertility: pathophysiology and current management.Journal of endocrinological investigation · 2016Review
Corrections and comments
- Erratum issued
Authors and funding
6 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
introductionThe aim of this study was to estimate the significance of TSH, thyroid peroxidase antibody (TPOAb), and mild (subclinical) hypothyroidism in women from The Danish General Suburban Population Study (GESUS) on the number of children born, the number of pregnancies, and the number of spontaneous abortions.
methodsRetrospective cross sectional study of 11254 women participating in GESUS. Data included biochemical measurements and a self-administrated questionnaire.
results6.7% had mild (subclinical) hypothyroidism and 9.4% prevalent hypothyroidism. In women with mild hypothyroidism TPOAb was significantly elevated and age at first child was older compared to controls. TSH and TPOAb were negatively linearly associated with the number of children born and the number of pregnancies in the full cohort in age-adjusted and multiadjusted models. TSH or TPOAb was not associated with spontaneous abortions. Mild (subclinical) hypothyroidism was associated with a risk of not having children and a risk of not getting pregnant in age-adjusted and multiadjusted models. Prevalent hypothyroidism was not associated with the number of children born, the number of pregnancies, or spontaneous abortions.
conclusionImpaired fertility is associated with TSH, TPOAb, and mild (subclinical) hypothyroidism in a Danish population of women.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.