Evidence map›Paper›PMID 26351578›Full record

ArticleInternational journal of hypertension2015

Preeclampsia Is Associated with Increased Central Aortic Pressure, Elastic Arteries Stiffness and Wave Reflections, and Resting and Recruitable Endothelial Dysfunction.

Juan Torrado, Ignacio Farro, Yanina Zócalo, Federico Farro, Claudio Sosa, Santiago Scasso, Justo Alonso, Daniel Bia

Open access · goldAbstract read
In one paragraph

Article in International journal of hypertension, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
20citing papers in PubMed, 2 pooled it
2.8field-weighted citation impact, top 10% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

20 citing papers in PubMed, 2 syntheses or guidelines pooled it, 41 citations in OpenAlex.

  1. Pooled it
  2. Preclinical atherosclerosis at the time of pre-eclamptic pregnancy and up to 10 years postpartum: systematic review and meta-analysis.Ultrasound in obstetrics & gynecology : the official journal of the International Society of Ultrasound in Obstetrics and Gynecology · 2017
    Pooled it
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  5. Hypertensive disorders of pregnancy & vascular dysfunction.Frontiers in cardiovascular medicine · 2024
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  15. Observational
  16. The profiles of soluble adhesion molecules in the "great obstetrical syndromes"The journal of maternal-fetal & neonatal medicine : the official journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians · 2019
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 2 institutions in 1 country.

Juan TorradoCentro Universitario de Investigación, Innovación y Diagnóstico Arterial (CUiiDARTE), Physiology Department, Faculty of Medicine, Republic University, 2125 General Flores, 11800 Montevideo, Uruguay.
Ignacio FarroCentro Universitario de Investigación, Innovación y Diagnóstico Arterial (CUiiDARTE), Physiology Department, Faculty of Medicine, Republic University, 2125 General Flores, 11800 Montevideo, Uruguay.
Yanina ZócaloCentro Universitario de Investigación, Innovación y Diagnóstico Arterial (CUiiDARTE), Physiology Department, Faculty of Medicine, Republic University, 2125 General Flores, 11800 Montevideo, Uruguay.
Federico FarroCentro Universitario de Investigación, Innovación y Diagnóstico Arterial (CUiiDARTE), Physiology Department, Faculty of Medicine, Republic University, 2125 General Flores, 11800 Montevideo, Uruguay.
Claudio SosaDepartment of Obstetrics and Gynecology "C", Pereira Rossell Hospital, Faculty of Medicine, Republic University, 1550 Bulevar Artigas, 11600 Montevideo, Uruguay.
Santiago ScassoDepartment of Obstetrics and Gynecology "C", Pereira Rossell Hospital, Faculty of Medicine, Republic University, 1550 Bulevar Artigas, 11600 Montevideo, Uruguay.
Justo AlonsoDepartment of Obstetrics and Gynecology "C", Pereira Rossell Hospital, Faculty of Medicine, Republic University, 1550 Bulevar Artigas, 11600 Montevideo, Uruguay.
Daniel BiaCentro Universitario de Investigación, Innovación y Diagnóstico Arterial (CUiiDARTE), Physiology Department, Faculty of Medicine, Republic University, 2125 General Flores, 11800 Montevideo, Uruguay.
Comisión Sectorial de Investigación Científica · UYCentro Hospitalario Pereira Rossell · UY

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Introduction. An altered endothelial function (EF) could be associated with preeclampsia (PE). However, more specific and complementary analyses are required to confirm this topic. Flow-mediated dilation (FMD), low-flow-mediated constriction (L-FMC), and hyperemic-related changes in carotid-radial pulse wave velocity (PWVcr) offer complementary information about "recruitability" of EF. Objectives. To evaluate, in healthy and hypertensive pregnant women (with and without PE), central arterial parameters in conjunction with "basal and recruitable" EF. Methods. Nonhypertensive (HP) and hypertensive pregnant women (gestational hypertension, GH; preeclampsia, PE) were included. Aortic blood pressure (BP), wave reflection parameters (AIx@75), aortic pulse wave velocity (PWVcf) and PWVcr, and brachial and common carotid stiffness and intima-media thickness were measured. Brachial FMD and L-FMC and hyperemic-related change in PWVcr were measured. Results. Aortic BP and AIx@75 were elevated in PE. PE showed stiffer elastic but not muscular arteries. After cuff deflation, PWVcr decreased in HP, while GH showed a blunted PWVcr response and PE showed a tendency to increase. Maximal FMD and L-FMC were observed in HP followed by GH; PE did not reach significant arterial constriction. Conclusion. Aortic BP and wave reflections as well as elastic arteries stiffness are increased in PE. PE showed both "resting and recruitable" endothelial dysfunctions.

Identifiers

PMID26351578
PMCPMC4550743
OpenAlexW1668228706

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.