Evaluation of the effect of physical variables on in vitro release of diclofenac pellets using Box-Behnken design.

Reza Enayatifard, Aiding Mahjoob, Pouneh Ebrahimi, Pedram Ebrahimnejad

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Article in Iranian journal of basic medical sciences, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

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1citing papers in PubMed

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1 citing paper in PubMed.

Solid Dispersion Pellets: An Efficient Pharmaceutical Approach to Enrich the Solubility and Dissolution Rate of Deferasirox.BioMed research international · 2020
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5 · Who and what money

Authors and funding

4 authors.

Reza EnayatifardPharmaceutical Sciences Research Center, Mazandaran University of Medical Sciences, Sari, Iran ; Department of Pharmaceutics, Faculty of Pharmacy, Mazandaran University of Medical Sciences, Sari, Iran.

Aiding MahjoobDepartment of Pharmaceutics, Faculty of Pharmacy, Mazandaran University of Medical Sciences, Sari, Iran.

Pouneh EbrahimiDepartment of Chemistry, Faculty of Basic Sciences, Golestan University, Gorgan, Iran.

Pedram EbrahimnejadPharmaceutical Sciences Research Center, Mazandaran University of Medical Sciences, Sari, Iran ; Department of Pharmaceutics, Faculty of Pharmacy, Mazandaran University of Medical Sciences, Sari, Iran.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectivesA Box-Behnken design was used for evaluation of Eudragit coated diclofenac pellets. The purpose of this work was to optimize diclofenac pellets to improve the physicochemical properties using experimental design. MATERIALS AND

methodsDiclofenac was loaded onto the non-pareil beads using conventional coating pan. Film coating of pellets was done at the same pan. The effect of plasticizer level, curing temperature and curing time was determined on the release of diclofenac from pellets coated with polymethacrylates.

resultsIncreasing the plasticizer in the coating formula led to decrease in drug release and increasing the curing temperature and time resulted in higher drug release. The optimization process generated an optimum of 35% drug release at 3 hr. The level of plasticizer concentration, curing temperature and time were 20% w/w, 55 °C and 24 hr, respectively.

conclusionThis study showed that by controllinig the physical variables optimum drug release were obtained.

Indexed as

Diclofenac sodiumEudragitOptimizationPelletPlasticizer

Identifiers

PMID26351563

PMCPMC4556766

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.