ArticleIranian journal of basic medical sciences2015
The anti-inflammatory effects of venlafaxine in the rat model of carrageenan-induced paw edema.
Article in Iranian journal of basic medical sciences, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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Who cites it
15 citing papers in PubMed, 35 citations in OpenAlex.
- Inhibitory effects of fluoxetine on the secretion of inflammatory mediators and JAK/STAT3 and JNK/TLR4 gene expression.Molecular biology reports · 2023Article
- Venlafaxine HCl Encapsulated in Niosome: Green and Eco-friendly Formulation for the Management of Pain.AAPS PharmSciTech · 2022Article
- Venlafaxine demonstrated anti-arthritic activity possibly through down regulation of TNF-α, IL-6, IL-1β, and COX-2.Inflammopharmacology · 2021Article
- Doxepin prevents the Expression and Development of Paclitaxel-Induced Neuropathic Pain.Advanced biomedical research · 2021Article
- Venlafaxine Attenuated the Cognitive and Memory Deficit in Mice Exposed to Isoflurane Alone.Frontiers in neurology · 2021Article
- Psychotropic Drugs for the Management of Chronic Pain and Itch.Pharmaceuticals (Basel, Switzerland) · 2019Review
- Minocycline through attenuation of oxidative stress and inflammatory response reduces the neuropathic pain in a rat model of chronic constriction injury.Iranian journal of basic medical sciences · 2018Article
- The effect of vitamin E and aspirin on the uterine artery blood flow in women with recurrent abortion: A single-blind randomized controlled trial.International journal of reproductive biomedicine · 2017Article
- Evaluation of the central and peripheral effects of doxepin on carrageenan-induced inflammatory paw edema in rat.Research in pharmaceutical sciences · 2017Article
- Relative Safety of Different Antidepressants for Treatment of Depression in Chronic Epileptic Animals Associated with Depression.Journal of epilepsy research · 2017Article
- Evaluation of central and peripheral effects of doxepin on acetic acid-induced colitis in rat and the involved mechanisms.EXCLI journal · 2017Article
- The Efficacy of Venlafaxine, Flunarizine, and Valproic Acid in the Prophylaxis of Vestibular Migraine.Frontiers in neurology · 2017Article
- Anti-inflammatory effect of longan seed extract in carrageenan stimulated Sprague-Dawley rats.Iranian journal of basic medical sciences · 2016Article
- Effect of mobile phone radiation on pentylenetetrazole-induced seizure threshold in mice.Iranian journal of basic medical sciences · 2016Article
- Periodontal status in chronic periodontitis depressed patients on desvenlafaxine: An observational study.Journal of Indian Society of PeriodontologyArticle
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Authors and funding
5 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectivesRecently anti-inflammatory effects of antidepressants have been demonstrated. Venlafaxine belongs to newer antidepressants with serotonin norepinephrine reuptake inhibition property. The pain alleviating properties of venlafaxine in different pain models such as neurogenic pain, diabetic neuropathy, and fibromyalgia have been demonstrated. Anti-inflammatory effects of venlafaxine and also its underlying mechanisms remain unclear. The present study was designed to evaluate the anti-inflammatory effects of venlafaxine and determine possible underlying mechanisms. MATERIALS AND
methodsWe examined the anti-inflammatory effects of intraperitoneal (IP) and intracerebroventricular (ICV) administration of venlafaxine in the rat model of carrageenan-induced paw edema.
resultsOur results showed that both IP (50 and 100 mg/kg) and ICV (50 and 100 μg/rat) injection of venlafaxine inhibited carrageenan-induced paw edema. Also IP and ICV administration of venlafaxine significantly decreased myeloperoxidase (MPO) activity and interleukin (IL)-1β and tumor necrosis factor (TNF)-α production. Finally, we tried to reverse the anti-inflammatory effect of venlafaxine by yohimbine (5 mg/kg, IP), an alpha2-adrenergic antagonist. Our results showed that applied antagonist failed to change the anti-inflammatory effect of venlafaxine.
conclusionThese results demonstrated that venlafaxine has potent anti-inflammatory effect which is related to the peripheral and central effects of this drug. Also we have shown that anti-inflammatory effect of venlafaxine is mediated mostly through the inhibition of IL-1β and TNF-α production and decreases MPO activity in the site of inflammation.
Indexed as
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26351555PMC4556757W1787731251What OpenQuestion holds
Registered trials
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