ArticleEvidence-based complementary and alternative medicine : eCAM2015
Antioxidant and Anticholinesterase Potential of Six Thymus Species.
Article in Evidence-based complementary and alternative medicine : eCAM, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers, 1 of them a synthesis that pooled it.
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Who cites it
21 citing papers in PubMed, 1 synthesis or guideline pooled it, 63 citations in OpenAlex.
- Wild thyme (Frontiers in nutrition · 2024Pooled it
- Species-Specific Metabolite Profiles and Biological Activities of BulgarianPlants (Basel, Switzerland) · 2026Article
- Exploring the metabolite composition and biological activities ofFrontiers in nutrition · 2025Article
- Src Tyrosine Kinase Inhibitory and Antioxidant Activity of Black Chokeberry and Bilberry Fruit Extracts Rich in Chlorogenic Acid.International journal of molecular sciences · 2023Article
- New Biological and Chemical Evidences of Two Lamiaceae Species (Molecules (Basel, Switzerland) · 2022Article
- In Vitro and In Silico Evaluation of the Antimicrobial and Antioxidant Potential ofAntioxidants (Basel, Switzerland) · 2022Article
- Comparative Antioxidant, Anti-Acetylcholinesterase and Anti-α-Glucosidase Activities of MediterraneanPlants (Basel, Switzerland) · 2022Article
- The Therapeutic Potential of Ethnomedicinally Important Anatolian Thyme Species: A Phytochemical and Biological Assessment.Frontiers in pharmacology · 2022Article
- TAK1/AP-1-Targeted Anti-Inflammatory Effects ofMolecules (Basel, Switzerland) · 2021Article
- Screening of Antioxidative Properties and Inhibition of Inflammation-Linked Enzymes by Aqueous and Ethanolic Extracts of Plants Traditionally Used in Wound Healing in Poland.Antioxidants (Basel, Switzerland) · 2021Article
- Article
- Biologically Active Compounds of Plants: Structure-Related Antioxidant, Microbiological and Cytotoxic Activity of Selected Carboxylic Acids.Materials (Basel, Switzerland) · 2020Review
- Health-Promoting Effects ofAntioxidants (Basel, Switzerland) · 2020Review
- Jujube (Zizyphus lotus L.): Benefits and its effects on functional and sensory properties of sponge cake.PloS one · 2020Article
- Chemical Characterization and Bioactivity of Extracts fromAntioxidants (Basel, Switzerland) · 2019Article
- Differentiation of Phenolic Composition Among TunisianAntioxidants (Basel, Switzerland) · 2019Article
- Metabolites and Biological Activities ofMolecules (Basel, Switzerland) · 2018Article
- In vitro Anti-cholinesterase and Anti-oxidant Activity of Three Standardised Polyherbal Products Used for Memory Enhancing in Ethnomedicine of South-East Nigeria.The Malaysian journal of medical sciences : MJMS · 2018Article
- Medicinal Plants of the Family Lamiaceae in Pain Therapy: A Review.Pain research & management · 2018Review
- Botanical Sources for Alzheimer's: A Review on Reports From Traditional Persian Medicine.American journal of Alzheimer's disease and other dementias · 2017Review
Corrections and comments
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Authors and funding
4 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The present study aimed to evaluate antioxidant and acetylcholinesterase (AChE) inhibitory activities of the ethanolic extracts of six selected Thymus species growing in Croatia (T. longicaulis, T. praecox subsp. polytrichus, T. pulegioides, T. serpyllum subsp. serpyllum, T. striatus, and T. vulgaris). Antioxidant effectiveness was assessed using six different assays, in comparison with rosmarinic acid, luteolin, and reference antioxidants. All tested Thymus extracts possessed DPPH (IC50 = 3-6 μg/mL) and nitric oxide (IC50 = 70-177 μg/mL) free radical scavenging activities, strong reducing properties (IC50 = 11-15 μg/mL), ferrous ion chelating activity (IC50 = 126-389 μg/mL), ability to inhibit lipid peroxidation (IC50 = 34-80 μg/mL), and high total antioxidant capacities (238-294 mg AAE/g). AChE inhibitory activity was examined using Ellman's colorimetric method and all tested extracts showed anti-AChE activity in a dose dependent manner. The values of 10-28%, 23-39%, and 64-86% were obtained for tested concentrations of 0.25, 0.5, and 1 mg/mL, respectively. Additionally, the contents of total hydroxycinnamic derivatives, flavonoids, and tannins in dried plant samples were determined spectrophotometrically. Our results highlighted Thymus species as a rich source of natural antioxidants and AChE inhibitors that could be useful in preventing and treating Alzheimer's disease and other neurodegenerative disorders.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.