ReviewBritish medical bulletin2015
Social and ethical issues in mitochondrial donation.
Review in British medical bulletin, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
23 citing papers in PubMed, 77 citations in OpenAlex.
- Mitochondrial translational control in cardiovascular diseases: from mechanisms to therapies.Redox biology · 2026Review
- Therapeutic Impact of Mitochondrial Transplants for Cardiovascular Diseases.International journal of molecular sciences · 2026Review
- Recent Advances in Mitochondrial Transplantation for Ischemic Stroke: A Review of in Vitro and in Vivo Studies.Translational stroke research · 2026Review
- Unlocking the potential of mitochondrial transplantation: overcoming challenges and paving the way for routine therapeutic application.Cytotechnology · 2025Review
- Mitochondrion-based organellar therapies for central nervous system diseases.Cell communication and signaling : CCS · 2024Review
- Mitochondria: A Potential Rejuvenation Tool against Aging.Aging and disease · 2024Review
- Mitochondrial transplantation as a promising therapy for mitochondrial diseases.Acta pharmaceutica Sinica. B · 2023Review
- Mitochondrial transplantation: opportunities and challenges in the treatment of obesity, diabetes, and nonalcoholic fatty liver disease.Journal of translational medicine · 2022Review
- Mitochondrial DNA Replacement Techniques to Prevent Human Mitochondrial Diseases.International journal of molecular sciences · 2021Review
- Review
- Overcoming bioethical, legal, and hereditary barriers to mitochondrial replacement therapy in the USA.Journal of assisted reproduction and genetics · 2019Article
- Does egg donation for mitochondrial replacement techniques generate parental responsibilities?Journal of medical ethics · 2018Article
- Lesbian motherhood and mitochondrial replacement techniques: reproductive freedom and genetic kinship.Journal of medical ethics · 2018Article
- Mitochondrial Replacement Techniques : Examining Collective Representation in Emerging Technologies Governance.Journal of bioethical inquiry · 2018Article
- Family Resemblances: Human Reproductive Cloning as an Example for Reconsidering the Mutual Relationships between Bioethics and Science Fiction.Journal of bioethical inquiry · 2018Article
- Sharpening the cutting edge: additional considerations for the UK debates on embryonic interventions for mitochondrial diseases.Life sciences, society and policy · 2017Article
- Genetic affinity and the right to 'three-parent IVF'.Journal of assisted reproduction and genetics · 2017Article
- Artificial Mitochondria Transfer: Current Challenges, Advances, and Future Applications.Stem cells international · 2017Review
- The (Re) Production of the Genetically Related Body in Law, Technology and Culture: Mitochondria Replacement Therapy.Health care analysis : HCA : journal of health philosophy and policy · 2016Article
- Streamlined analysis of duplex sequencing data with Du Novo.Genome biology · 2016Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
1 author at 1 institution in 1 country.
Funding
Abstract
INTRODUCTION OR
backgroundThe UK is at the forefront of mitochondrial science and is currently the only country in the world to legalize germ-line technologies involving mitochondrial donation. However, concerns have been raised about genetic modification and the 'slippery slope' to designer babies. SOURCES OF DATA: This review uses academic articles, newspaper reports and public documents. AREAS OF AGREEMENT: Mitochondrial donation offers women with mitochondrial disease an opportunity to have healthy, genetically related children. AREAS OF CONTROVERSY: Key areas of disagreement include safety, the creation of three-parent babies, impact on identity, implications for society, definitions of genetic modification and reproductive choice. GROWING POINTS: The UK government legalized the techniques in March 2015. Scientific and medical communities across the world followed the developments with interest. AREAS TIMELY FOR DEVELOPING RESEARCH: It is expected that the first cohort of 'three parent' babies will be born in the UK in 2016. Their health and progress will be closely monitored.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.