Evidence map›Paper›PMID 26351362›Full record

ReviewStroke2015

Imaging Inflammation in Cerebrovascular Disease.

Matthew J Gounis, Kajo van der Marel, Miklos Marosfoi, Mary L Mazzanti, Frédéric Clarençon, Ju-Yu Chueh, Ajit S Puri, Alexei A Bogdanov

Abstract readReview
In one paragraph

Review in Stroke, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
14citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

14 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Trial
  3. Article
  4. Blind spots in brain imaging: a pictorial essay.Quantitative imaging in medicine and surgery · 2025
    Review
  5. Vessel wall imaging and quantitative flow assessment in arteriovenous malformations: A feasibility study.Interventional neuroradiology : journal of peritherapeutic neuroradiology, surgical procedures and related neurosciences · 2024
    Article
  6. Toll-like receptors in cardiac hypertrophy.Frontiers in cardiovascular medicine · 2023
    Review
  7. Article
  8. Review
  9. Consensus statement on current and emerging methods for the diagnosis and evaluation of cerebrovascular disease.Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism · 2018
    Review
  10. Article
  11. Article
  12. Article
  13. Large Artery Atherosclerotic Occlusive Disease.Continuum (Minneapolis, Minn.) · 2017
    Review
  14. Brain Vascular Imaging Techniques.International journal of molecular sciences · 2016
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Matthew J GounisFrom the New England Center for Stroke Research (M.J.G., K.v.d.M., M.M., F.C., J.-Y.C., A.S.P.) and Laboratory of Molecular Imaging Probes (M.L.M., A.A.B.), Department of Radiology, University of Massachusetts Medical School, Worcester. matt.gounis@umassmed.edu.
Kajo van der MarelFrom the New England Center for Stroke Research (M.J.G., K.v.d.M., M.M., F.C., J.-Y.C., A.S.P.) and Laboratory of Molecular Imaging Probes (M.L.M., A.A.B.), Department of Radiology, University of Massachusetts Medical School, Worcester.
Miklos MarosfoiFrom the New England Center for Stroke Research (M.J.G., K.v.d.M., M.M., F.C., J.-Y.C., A.S.P.) and Laboratory of Molecular Imaging Probes (M.L.M., A.A.B.), Department of Radiology, University of Massachusetts Medical School, Worcester.
Mary L MazzantiFrom the New England Center for Stroke Research (M.J.G., K.v.d.M., M.M., F.C., J.-Y.C., A.S.P.) and Laboratory of Molecular Imaging Probes (M.L.M., A.A.B.), Department of Radiology, University of Massachusetts Medical School, Worcester.
Frédéric ClarençonFrom the New England Center for Stroke Research (M.J.G., K.v.d.M., M.M., F.C., J.-Y.C., A.S.P.) and Laboratory of Molecular Imaging Probes (M.L.M., A.A.B.), Department of Radiology, University of Massachusetts Medical School, Worcester.
Ju-Yu ChuehFrom the New England Center for Stroke Research (M.J.G., K.v.d.M., M.M., F.C., J.-Y.C., A.S.P.) and Laboratory of Molecular Imaging Probes (M.L.M., A.A.B.), Department of Radiology, University of Massachusetts Medical School, Worcester.
Ajit S PuriFrom the New England Center for Stroke Research (M.J.G., K.v.d.M., M.M., F.C., J.-Y.C., A.S.P.) and Laboratory of Molecular Imaging Probes (M.L.M., A.A.B.), Department of Radiology, University of Massachusetts Medical School, Worcester.
Alexei A BogdanovFrom the New England Center for Stroke Research (M.J.G., K.v.d.M., M.M., F.C., J.-Y.C., A.S.P.) and Laboratory of Molecular Imaging Probes (M.L.M., A.A.B.), Department of Radiology, University of Massachusetts Medical School, Worcester.

Funding

MR SIGNAL AMPLIFICATION FOR RECEPTOR IMAGINGR01EB000858 · NIBIB · UNIV OF MASSACHUSETTS MED SCH WORCESTER · PI BOGDANOV, ALEXEI A. · 2003 to 2022
$6.0M
Unruptured Intracranial Aneurysms: Rupture-Risk Assessment by Non-Invasive Molecular ImagingR01NS091552 · NINDS · UNIV OF MASSACHUSETTS MED SCH WORCESTER · PI BOGDANOV, ALEXEI A., GOUNIS, MATTHEW JOHN · 2015 to 2018
$2.1M
Molecular fluorescence lifetime sensor of pro-inflammatory signaling in diabetesR01DK095728 · NIDDK · UNIV OF MASSACHUSETTS MED SCH WORCESTER · PI BOGDANOV, ALEXEI A. · 2014 to 2017
$1.5M
Molecular Imaging Probes for Reporting on Vascular Oxidative ResponseR01AG034901 · NIA · UNIV OF MASSACHUSETTS MED SCH WORCESTER · PI BOGDANOV, ALEXEI A. · 2010 to 2013
$1.3M
NIA NIH HHS R01 AG034901NIBIB NIH HHS R01 EB000858NIDDK NIH HHS R01 DK095728NINDS NIH HHS R01 NS091552
6 · The paper itself

Abstract

Imaging inflammation in large intracranial artery pathology may play an important role in the diagnosis of and risk stratification for a variety of cerebrovascular diseases. Looking beyond the lumen has already generated widespread excitement in the stroke community, and the potential to unveil molecular processes in the vessel wall is a natural evolution to develop a more comprehensive understanding of the pathogenesis of diseases, such as ICAD and brain aneurysms.

Indexed as

Blood VesselsBrainCerebral AngiographyCerebrovascular DisordersEchoencephalographyHumansMagnetic Resonance ImagingMolecular ImagingPositron-Emission TomographyVasculitis, Central Nervous Systemaneurysminflammationintracranial atherosclerosismolecular imagingMRIvasculitisvasculopathy

Identifiers

PMID26351362
PMCPMC4589518

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.