ArticleJournal of experimental botany2015
KNOTTED1-LIKE HOMEOBOX 3: a new regulator of symbiotic nodule development.
Article in Journal of experimental botany, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers.
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Who cites it
26 citing papers in PubMed, 77 citations in OpenAlex.
- Organized peripheral vascular strand development in nodules is controlled by a bHLH/HLH heterodimer.The New phytologist · 2026Article
- Innovations in functional genomics and molecular breeding of pea: exploring advances and opportunities.aBIOTECH · 2024Review
- Rhizobial nitrogen fixation efficiency shapes endosphere bacterial communities and Medicago truncatula host growth.Microbiome · 2023Article
- Comparative phylotranscriptomics reveals ancestral and derived root nodule symbiosis programmes.Nature plants · 2023Article
- Exogenously Applied Cytokinin Altered the Bacterial Release and Subsequent Stages of Nodule Development in PeaPlants (Basel, Switzerland) · 2023Article
- Comparative analysis ofFrontiers in plant science · 2023Article
- The PagKNAT2/6b-PagBOP1/2a Regulatory Module Controls Leaf Morphogenesis inInternational journal of molecular sciences · 2022Article
- Spatiotemporal cytokinin response imaging and ISOPENTENYLTRANSFERASE 3 function in Medicago nodule development.Plant physiology · 2022Article
- Regulation of the Later Stages of Nodulation Stimulated by IPD3/CYCLOPS Transcription Factor and Cytokinin in PeaPlants (Basel, Switzerland) · 2021Article
- At the Root of Nodule Organogenesis: Conserved Regulatory Pathways Recruited by Rhizobia.Plants (Basel, Switzerland) · 2021Review
- The Regulation of Nodule Number in Legumes Is a Balance of Three Signal Transduction Pathways.International journal of molecular sciences · 2021Review
- Evolutionary Relationships and Divergence of KNOTTED1-Like Family Genes Involved in Salt Tolerance and Development in Cotton (Frontiers in plant science · 2021Article
- Identification of BELL Transcription Factors Involved in Nodule Initiation and Development in the LegumesPlants (Basel, Switzerland) · 2020Article
- Symbiotic Regulatory Genes Controlling Nodule Development inPlants (Basel, Switzerland) · 2020Review
- Article
- Cytokinin biosynthesis genes expressed during nodule organogenesis are directly regulated by the KNOX3 protein in Medicago truncatula.PloS one · 2020Article
- Genome-Wide Identification of theFrontiers in plant science · 2020Article
- Gene Expression in Nitrogen-Fixing Symbiotic Nodule Cells inThe Plant cell · 2020Review
- The DELLA Proteins Influence the Expression of Cytokinin Biosynthesis and Response Genes During Nodulation.Frontiers in plant science · 2019Article
- Article
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Authors and funding
6 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
KNOX transcription factors (TFs) regulate different aspects of plant development essentially through their effects on phytohormone metabolism. In particular, KNOX TF SHOOTMERISTEMLESS activates the cytokinin biosynthesis ISOPENTENYL TRANSFERASE (IPT) genes in the shoot apical meristem. However, the role of KNOX TFs in symbiotic nodule development and their possible effects on phytohormone metabolism during nodulation have not been studied to date. Cytokinin is a well-known regulator of nodule development, playing the key role in the regulation of cell division during nodule primordium formation. Recently, the activation of IPT genes was shown to take place during nodulation. Therefore, it was hypothesized that KNOX TFs may regulate nodule development and activate cytokinin biosynthesis upon nodulation. This study analysed the expression of different KNOX genes in Medicago truncatula Gaertn. and Pisum sativum L. Among them, the KNOX3 gene was upregulated in response to rhizobial inoculation in both species. pKNOX3::GUS activity was observed in developing nodule primordium. KNOX3 ectopic expression caused the formation of nodule-like structures on transgenic root without bacterial inoculation, a phenotype similar to one described previously for legumes with constitutive activation of the cytokinin receptor. Furthermore, in transgenic roots with MtKNOX3 knockdown, downregulation of A-type cytokinin response genes was found, as well as the MtIPT3 and LONELYGUY2 (MtLOG2) gene being involved in cytokinin activation. Taken together, these findings suggest that KNOX3 gene is involved in symbiotic nodule development and may regulate cytokinin biosynthesis/activation upon nodule development in legume plants.
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