Evidence map›Paper›PMID 26351279›Full record

ArticleInfection and immunity2015

TIR Domain-Containing Adapter-Inducing Beta Interferon (TRIF) Mediates Immunological Memory against Bacterial Pathogens.

Saravana Kanagavelu, Claudia Flores, J M Termini, Laura Romero, Reldy Riveron, Jose Ruiz, Moshe Arditi, Kurt Schesser, Masayuki Fukata

Open access · bronzeAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Infection and immunity, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.4field-weighted citation impact, top 37% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 4 citations in OpenAlex.

  1. Review
  2. Article
  3. TIR-Domain-Containing Adapter-Inducing Interferon-Journal of clinical & cellular immunology · 2016
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 2 institutions in 1 country.

Saravana KanagaveluDivision of Gastroenterology, Department of Medicine, Inflammatory Bowel and Immunobiology Research Institute, Cedars-Sinai Medical Center, Los Angeles, California, USA.
Claudia FloresDivision of Gastroenterology, Department of Medicine, Inflammatory Bowel and Immunobiology Research Institute, Cedars-Sinai Medical Center, Los Angeles, California, USA.
J M TerminiDepartment of Microbiology and Immunology, University of Miami Miller School of Medicine, Miami, Florida, USA.
Laura RomeroDivision of Gastroenterology, Department of Medicine, University of Miami Miller School of Medicine, Miami, Florida, USA.
Reldy RiveronDivision of Gastroenterology, Department of Medicine, University of Miami Miller School of Medicine, Miami, Florida, USA.
Jose RuizDivision of Gastroenterology, Department of Medicine, University of Miami Miller School of Medicine, Miami, Florida, USA.
Moshe ArditiDivision of Pediatric Infectious Diseases and Immunology, Cedars-Sinai Medical Center, Los Angeles, California, USA Department of Biomedical Sciences, Cedars-Sinai Medical Center, Los Angeles, California, USA.
Kurt SchesserDepartment of Microbiology and Immunology, University of Miami Miller School of Medicine, Miami, Florida, USA.
Masayuki FukataDivision of Gastroenterology, Department of Medicine, Inflammatory Bowel and Immunobiology Research Institute, Cedars-Sinai Medical Center, Los Angeles, California, USA Department of Biomedical Sciences, Cedars-Sinai Medical Center, Los Angeles, California, USA Department of Medicine, David Geffen School of Medicine, University of California, Los Angeles, California, USA Masayuki.fukata@cshs.org.
University of Miami · USCedars-Sinai Medical Center · US

Funding

Role of TRIF-Dependent TLR Signaling in Intestinal MucosaR01AI095255 · NIAID · UNIVERSITY OF MIAMI SCHOOL OF MEDICINE · PI TARGAN, STEPHAN R. · 2012 to 2021
$3.8M
Role of TRIF-dependent TLR signaling in intestinal immunityR56AI095255 · NIAID · UNIVERSITY OF MIAMI SCHOOL OF MEDICINE · PI FUKATA, MASAYUKI · 2011 to 2011
$383k
NIAID NIH HHS AI095255NIAID NIH HHS R01 AI095255NIAID NIH HHS R56 AI095255
6 · The paper itself

Abstract

Induction of adaptive immunity leads to the establishment of immunological memory; however, how innate immunity regulates memory T cell function remains obscure. Here we show a previously undefined mechanism in which innate and adaptive immunity are linked by TIR domain-containing adapter-inducing beta interferon (TRIF) during establishment and reactivation of memory T cells against Gram-negative enteropathogens. Absence of TRIF in macrophages (Mϕs) but not dendritic cells led to a predominant generation of CD4(+) central memory T cells that express IL-17 during enteric bacterial infection in mice. TRIF-dependent type I interferon (IFN) signaling in T cells was essential to Th1 lineage differentiation and reactivation of memory T cells. TRIF activated memory T cells to facilitate local neutrophil influx and enhance bacterial elimination. These results highlight the importance of TRIF as a mediator of the innate and adaptive immune interactions in achieving the protective properties of memory immunity against Gram-negative bacteria and suggest TRIF as a potential therapeutic target.

Indexed as

Immunologic MemoryAdaptor Proteins, Vesicular TransportAnimalsDendritic CellsHumansInterferon-gammaInterleukin-17MacrophagesMaleMiceMice, Inbred C57BLT-LymphocytesYersinia enterocoliticaYersinia InfectionsAdaptor Proteins, Vesicular TransportInterferon-gammaInterleukin-17Ticam1 protein, mouse

Identifiers

PMID26351279
PMCPMC4598391
OpenAlexW2100897883

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.