ReviewChild's nervous system : ChNS : official journal of the International Society for Pediatric Neurosurgery2015
Posterior fossa tumors in infants and neonates.
Review in Child's nervous system : ChNS : official journal of the International Society for Pediatric Neurosurgery, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers, 2 of them syntheses that pooled it.
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Who cites it
13 citing papers in PubMed, 2 syntheses or guidelines pooled it, 30 citations in OpenAlex.
- Neurological vertigo in the emergency room in pediatric and adult age: systematic literature review and proposal for a diagnostic algorithm.Italian journal of pediatrics · 2022Pooled it
- Arterial Spin-Labeling in Children with Brain Tumor: A Meta-Analysis.AJNR. American journal of neuroradiology · 2018Pooled it
- Recent Advances in Pediatric Medulloblastoma.Current neurology and neuroscience reports · 2023Review
- Intracranial Tumors in the First Year of Life.Advances and technical standards in neurosurgery · 2023Article
- Resection of posterior fossa tumors in the semi-sitting position in children younger than 4 years of age.Child's nervous system : ChNS : official journal of the International Society for Pediatric Neurosurgery · 2023Article
- Posterior Fossa Tumours in the First Year of Life: A Two-Centre Retrospective Study.Diagnostics (Basel, Switzerland) · 2022Article
- Risk factors for surgical site infection in pediatric posterior fossa tumors.Child's nervous system : ChNS : official journal of the International Society for Pediatric Neurosurgery · 2021Article
- Predicting postoperative tracheostomy requirement in children undergoing surgery for posterior fossa tumors.Child's nervous system : ChNS : official journal of the International Society for Pediatric Neurosurgery · 2020Article
- Predicting dysphagia in children undergoing surgery for posterior fossa tumors.Child's nervous system : ChNS : official journal of the International Society for Pediatric Neurosurgery · 2020Article
- Freiburg Neuropathology Case Conference : Posterior Fossa Mass in an Infant.Clinical neuroradiology · 2019Article
- Synergistic anti-cancer effects of epigenetic drugs on medulloblastoma cells.Cellular oncology (Dordrecht, Netherlands) · 2017Article
- Incidence, time trends and survival patterns of childhood pilocytic astrocytomas in Southern-Eastern Europe and SEER, US.Journal of neuro-oncology · 2017Article
- SOX10 Distinguishes Pilocytic and Pilomyxoid Astrocytomas From Ependymomas but Shows No Differences in Expression Level in Ependymomas From Infants Versus Older Children or Among Molecular Subgroups.Journal of neuropathology and experimental neurology · 2016Article
Corrections and comments
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Authors and funding
10 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
introductionManagement of posterior fossa tumors in infants and neonates is challenging. The characteristics of the young babies make surgery very difficult, sometimes precluding a safe complete removal.
methodsA review of the literature was undertaken to examine the incidence, histology, surgical aspects, and prognosis of posterior fossa tumors in the first year of life. Therapeutical strategies of the most frequent tumor types are also discussed in detail.
resultsHistology is dominated by tumors with aggressive behavior, such as medulloblastomas, atypical teratoid/rhabdoid tumors, and anaplastic ependymomas. The most important surgical considerations in small children are the small circulating blood volume; the poor thermoregulation; and incomplete maturation of the brain, of the skull, and of the soft tissue. Treatment toxicity is inversely related to the age of the patients. Radiation therapy is usually considered as contraindicated in young children, with few exceptions. Proton therapy is a promising tool, but access to this kind of treatment is still limited. The therapeutic limitations of irradiation render resection of this tumor and adjuvant chemotherapy often the only therapeutic strategy in many cases.
conclusionsThe overall prognosis remains dismal because of the prevalent aggressive histologies, the surgical challenges, and the limitations of adjuvant treatment. Nevertheless, the impressive improvements in anesthesiology and surgical techniques allow, in the vast majority of the cases, complete removal of the lesions with minor sequelae in high-volume referral pediatric centers.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.