ReviewNeuroradiology2015
A neuroradiologist's guide to arterial spin labeling MRI in clinical practice.
Review in Neuroradiology, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 157 papers, 6 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
157 citing papers in PubMed, 6 syntheses or guidelines pooled it, 293 citations in OpenAlex.
- ESR Essentials: Perfusion MRI-practice recommendations by the European Society for Magnetic Resonance in Medicine and Biology.European radiology · 2026Guideline
- Arterial spin labeling MRI in assessing cerebral blood flow changes due to hypertension: a systematic review.Journal of hypertension · 2026Pooled it
- Arterial spin labelling magnetic resonance imaging and perfusion patterns in neurocognitive and other mental disorders: a systematic review.Neuroradiology · 2024Pooled it
- Association between cerebral perfusion and paediatric postoperative cerebellar mutism syndrome after posterior fossa surgery-a systematic review.Child's nervous system : ChNS : official journal of the International Society for Pediatric Neurosurgery · 2021Pooled it
- A comparison of arterial spin labelling with catheter angiography in evaluating arteriovenous malformations: a systematic review.The British journal of radiology · 2020Pooled it
- The effect of phosphodiesterase-5 inhibitors on cerebral blood flow in humans: A systematic review.Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism · 2018Pooled it
- Intrathecal versus intravenous umbilical cord mesenchymal stem cells for ischemic stroke sequelae.Stem cells translational medicine · 2025Trial
- Repetitive transcranial magnetic stimulation (rTMS) in alcohol dependence: study protocol of a randomized controlled clinical trial of efficacy and working mechanisms.BMC psychiatry · 2018Trial
- Trial
- Denoising of ASL Data Using Deep Learning Priors Generated From Distribution Remapping.Magnetic resonance in medicine · 2026Article
- Enhancing Cerebral Blood Flow Quantification: A Comprehensive Review of Denoising, Artifact Correction, and Simulation in Arterial Spin Labeling MRI.Sensors (Basel, Switzerland) · 2026Review
- Comparative study of radiomics features between ASL and DSC perfusion-weighted imaging in distinguishing radiation-induced brain injury from glioma recurrence.Neuroradiology · 2026Article
- Aging and metabolism contribute separately to brain-body health.PLoS biology · 2026Article
- Acute cannabidiol (CBD), tetrahydrocannabinol (THC) and their mixture (THC:CBD) exert differential effects on brain activity and blood flow in rats: A translational neuroimaging study.Journal of psychopharmacology (Oxford, England) · 2026Article
- Perfusion Signal Analysis Using Multi-pulsed Arterial Spin Labeling (mPASL) with Multiple Post-labeling Delays: Phantom Validation and Application to the Human Foot.Magnetic resonance in medical sciences : MRMS : an official journal of Japan Society of Magnetic Resonance in Medicine · 2026Article
- Advanced neuroimaging assessment of neurodegenerative dementia syndromes: A framework for comprehensive multimodal FDG-PET, MR-perfusion, and MR-diffusion analysis.NeuroImage. Clinical · 2026Article
- Differentiating tumor recurrence and pseudoprogression in postoperative gliomas using pseudo-continuous arterial spin labeling (pCASL) technique.BMC medical imaging · 2025Article
- Age-Related Alterations of Cerebral Autoregulation.Life (Basel, Switzerland) · 2025Review
- Using the latent diffusion model to enhance time-resolved laser speckle contrast imaging (TR-LSCI) of cerebral blood flow.Biomedical optics express · 2025Article
- Predictor value of pCASL maps on final core in acute ischemic stroke: an observational single‑center study.Neuroradiology · 2025Observational
97 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors at 5 institutions in 5 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Arterial spin labeling (ASL) is a non-invasive MRI technique to measure cerebral blood flow (CBF). This review provides a practical guide and overview of the clinical applications of ASL of the brain, as well its potential pitfalls. The technical and physiological background is also addressed. At present, main areas of interest are cerebrovascular disease, dementia and neuro-oncology. In cerebrovascular disease, ASL is of particular interest owing to its quantitative nature and its capability to determine cerebral arterial territories. In acute stroke, the source of the collateral blood supply in the penumbra may be visualised. In chronic cerebrovascular disease, the extent and severity of compromised cerebral perfusion can be visualised, which may be used to guide therapeutic or preventative intervention. ASL has potential for the detection and follow-up of arteriovenous malformations. In the workup of dementia patients, ASL is proposed as a diagnostic alternative to PET. It can easily be added to the routinely performed structural MRI examination. In patients with established Alzheimer's disease and frontotemporal dementia, hypoperfusion patterns are seen that are similar to hypometabolism patterns seen with PET. Studies on ASL in brain tumour imaging indicate a high correlation between areas of increased CBF as measured with ASL and increased cerebral blood volume as measured with dynamic susceptibility contrast-enhanced perfusion imaging. Major advantages of ASL for brain tumour imaging are the fact that CBF measurements are not influenced by breakdown of the blood-brain barrier, as well as its quantitative nature, facilitating multicentre and longitudinal studies.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.