Evidence map›Paper›PMID 26351137›Full record

ArticleOrganic & biomolecular chemistry2015

RGD-conjugated two-photon absorbing near-IR emitting fluorescent probes for tumor vasculature imaging.

Xiling Yue, Alma R Morales, Grace W Githaiga, Adam W Woodward, Simon Tang, Junko Sawada, Masanobu Komatsu, Xuan Liu, Kevin D Belfield

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Organic & biomolecular chemistry, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
1.6field-weighted citation impact, top 18% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 19 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 5 institutions in 4 countries.

Xiling YueDepartment of Chemistry, University of Central Florida, P.O. Box 162366, Orlando, FL 32816, USA.
Alma R MoralesInstitute of Chemical Sciences and Engineering, Swiss Federal Institute of Technology of Lausanne, Lausanne, Switzerland.
Grace W GithaigaDepartment of Chemistry, University of Central Florida, P.O. Box 162366, Orlando, FL 32816, USA.
Adam W WoodwardDepartment of Chemistry, University of Central Florida, P.O. Box 162366, Orlando, FL 32816, USA.
Simon TangDepartment of Chemistry, University of Central Florida, P.O. Box 162366, Orlando, FL 32816, USA.
Junko SawadaSanford-Burnham Medical Research Institute at Lake Nona, Orlando, FL 32827, USA.
Masanobu KomatsuSanford-Burnham Medical Research Institute at Lake Nona, Orlando, FL 32827, USA.
Xuan LiuDepartment of Electrical and Computer Engineering, New Jersey Institute of Technology, University Heights, Newark, NJ 07102, USA.
Kevin D BelfieldCollege of Science and Liberal Arts, New Jersey Institute of Technology, University Heights, Newark, NJ 07102, USA. belfield@njit.edu.
University of Central Florida · USSanford Burnham Prebys Medical Discovery Institute · USÉcole Polytechnique Fédérale de Lausanne · CHNewark Hospital · GBNew Jersey Institute of Technology · US

Funding

Normalization of tumor vasculature by R-RasR01CA125255 · NCI · SANFORD BURNHAM PREBYS MEDICAL DISCOVERY INSTITUTE · PI KOMATSU, MASANOBU · 2008 to 2018
$4.2M
NCI NIH HHS 2R01CA125255NCI NIH HHS R01 CA125255
6 · The paper itself

Abstract

Observation of the activation and inhibition of angiogenesis processes is important in the progression of cancer. Application of targeting peptides, such as a small peptide that contains adjacent L-arginine (R), glycine (G) and L-aspartic acid (D) residues can afford high selectivity and deep penetration in vessel imaging. To facilitate deep tissue vasculature imaging, probes that can be excited via two-photon absorption (2PA) in the near-infrared (NIR) and subsequently emit in the NIR are essential. In this study, the enhancement of tissue image quality with RGD conjugates was investigated with new NIR-emitting pyranyl fluorophore derivatives in two-photon fluorescence microscopy. Linear and nonlinear photophysical properties of the new probes were comprehensively characterized; significantly the probes exhibited good 2PA over a broad spectral range from 700-1100 nm. Cell and tissue images were then acquired and examined, revealing deep penetration and high contrast with the new pyranyl RGD-conjugates up to 350 μm in tumor tissue.

Indexed as

AnimalsCarcinoma, Lewis LungFluorescent DyesHumansInfrared RaysIntegrinsMiceMice, Inbred C57BLMicroscopy, Fluorescence, MultiphotonNanoparticlesNeoplasmsOligopeptidesOptical ImagingPhotonsarginyl-glycyl-aspartic acidFluorescent DyesIntegrinsOligopeptides

Identifiers

PMID26351137
PMCPMC4627496
OpenAlexW1759524199

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.