ArticleJournal of biomechanics2015
Loading-induced changes on topographical distributions of the zonal properties of osteoarthritic tibial cartilage--A study by magnetic resonance imaging at microscopic resolution.
Article in Journal of biomechanics, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers, 1 of them a synthesis that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
11 citing papers in PubMed, 1 synthesis or guideline pooled it, 13 citations in OpenAlex.
- Exosome-Laden Scaffolds for Treatment of Post-Traumatic Cartilage Injury and Osteoarthritis of the Knee: A Systematic Review.International journal of molecular sciences · 2023Pooled it
- Repeatability of focal changes in knee cartilage TOsteoarthritis imaging · 2025Article
- Depth-wise multiparametric assessment of articular cartilage layers with single-sided NMR.NMR in biomedicine · 2025Article
- Characteristics of distal femoral articular cartilage in 6 weeks posttraumatic osteoarthritis by a subcritical impact.Journal of orthopaedic research : official publication of the Orthopaedic Research Society · 2024Article
- Topographical and zonal patterns of T2 relaxation in osteoarthritic tibial cartilage by low- and high-resolution MRI.Magnetic resonance imaging · 2021Article
- Compressed sensing in quantitative determination of GAG concentration in cartilage by microscopic MRI.Magnetic resonance in medicine · 2018Article
- Diagnostic utility of fluorogenic peptide-conjugated Au nanoparticle probe corroborated by rabbit model of mild cartilage injury and panel of osteoarthritic patients.American journal of translational research · 2018Article
- Image interpolation improves the zonal analysis of cartilage T2 relaxation in MRI.Quantitative imaging in medicine and surgery · 2017Article
- Topographical and depth-dependent glycosaminoglycan concentration in canine medial tibial cartilage 3 weeks after anterior cruciate ligament transection surgery-a microscopic imaging study.Quantitative imaging in medicine and surgery · 2016Article
- Meniscus Induced Cartilaginous Damage and Non-linear Gross Anatomical Progression of Early-stage Osteoarthritis in a Canine Model.The open orthopaedics journal · 2016Article
- Detection of early osteoarthritis in canine knee joints 3 weeks post ACL transection by microscopic MRI and biomechanical measurement.Journal of orthopaedic surgery (Hong Kong)Article
Corrections and comments
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Authors and funding
6 authors at 2 institutions in 2 countries.
Funding
Abstract
The topographical distributions of the zonal properties of articular cartilage over the medial tibia from an experimental osteoarthritis (OA) model were evaluated as a function of external loading by microscopic Magnetic Resonance Imaging (µMRI). T2 relaxation times and cartilage thicknesses were measured at 17.6 µm resolution from 118 specimens, which came from thirteen dogs (six 8-week and seven 12-week after surgery), with and without mechanical loading. In addition, bulk mechanical modulus was measured topographically from each tibia surface. The total thickness decreased significantly under the external loading, in which the relative thickness of the superficial zone (SZ) and the transitional zone (TZ) increased whereas the radial zones (RZs) decreased. In the bulk data, T2(55°) decreased significantly (p<0.001) at all OA-time-points, but T2(0°) decreased without significance (p>0.05) at 8-week. Complex relationships were found in the zonal tissue properties as a function of external loading with the progress of OA. T2 in the superficial zone changed more profoundly than the same properties in the radial zone as a function of external loading at all OA time-points. This study confirms that OA affects the load-induced changes in the molecular distribution and structure of cartilage, which are both depth-dependent and topographically distributed. Such detailed knowledge of mechanobiological changes in specific tibial cartilage zones and locations with OA progress could improve the early detection of the subtle softening of cartilage that accompanies pre-clinical stages of OA.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.