ArticlemBio2015
The Complete Genome Sequence of Clostridium aceticum: a Missing Link between Rnf- and Cytochrome-Containing Autotrophic Acetogens.
Article in mBio, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 44 papers.
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Who cites it
44 citing papers in PubMed, 81 citations in OpenAlex.
- Defined Electrosynthetic Microbial Consortia Reveal Electron Transfer Modes Governing Acetate Production.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026Article
- Sugar-inducible promoters for manipulation of core metabolic pathways in the thermophilic acetogenApplied and environmental microbiology · 2025Article
- Isolation and characterization of novel acetogenic strains of the generaFrontiers in microbiology · 2024Article
- Reduction, evolutionary pattern and positive selection of genes encoding formate dehydrogenase in Wood-Ljungdahl pathway of gastrointestinal acetogens suggests their adaptation to formate-rich habitats.Environmental microbiology reports · 2023Article
- DNA uptake from a laboratory environment drives unexpected adaptation of a thermophile to a minor medium component.ISME communications · 2023Article
- Article
- Engineering Acetogenic Bacteria for Efficient One-Carbon Utilization.Frontiers in microbiology · 2022Review
- Production of Hexanol as the Main Product Through Syngas Fermentation byFrontiers in bioengineering and biotechnology · 2022Article
- Energy conservation under extreme energy limitation: the role of cytochromes and quinones in acetogenic bacteria.Extremophiles : life under extreme conditions · 2021Review
- Energy Conservation in the Acetogenic BacteriumMicroorganisms · 2021Article
- Bioaugmented Mixed Culture byFrontiers in microbiology · 2021Article
- Homologous production, one-step purification, and proof of NaBiotechnology for biofuels · 2020Article
- Synthetic Biology on Acetogenic Bacteria for Highly Efficient Conversion of C1 Gases to Biochemicals.International journal of molecular sciences · 2020Review
- Diverse Energy-Conserving Pathways in Clostridium difficile: Growth in the Absence of Amino Acid Stickland Acceptors and the Role of the Wood-Ljungdahl Pathway.Journal of bacteriology · 2020Article
- Metagenome Sequences of a Wastewater Treatment Plant Digester Sludge-Derived Enrichment Culture.Microbiology resource announcements · 2020Article
- Functional cooperation of the glycine synthase-reductase and Wood-Ljungdahl pathways for autotrophic growth ofProceedings of the National Academy of Sciences of the United States of America · 2020Article
- Complete Genome Sequence of Sporomusa termitida DSM 4440Microbiology resource announcements · 2020Article
- Single-Cell Genomics of Novel Actinobacteria With the Wood-Ljungdahl Pathway Discovered in a Serpentinizing System.Frontiers in microbiology · 2020Article
- Enhancing COFrontiers in bioengineering and biotechnology · 2020Article
- Overcoming Energetic Barriers in Acetogenic C1 Conversion.Frontiers in bioengineering and biotechnology · 2020Review
Corrections and comments
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Authors and funding
10 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
unlabelledClostridium aceticum was the first isolated autotrophic acetogen, converting CO2 plus H2 or syngas to acetate. Its genome has now been completely sequenced and consists of a 4.2-Mbp chromosome and a small circular plasmid of 5.7 kbp. Sequence analysis revealed major differences from other autotrophic acetogens. C. aceticum contains an Rnf complex for energy conservation (via pumping protons or sodium ions). Such systems have also been found in C. ljungdahlii and Acetobacterium woodii. However, C. aceticum also contains a cytochrome, as does Moorella thermoacetica, which has been proposed to be involved in the generation of a proton gradient. Thus, C. aceticum seems to represent a link between Rnf- and cytochrome-containing autotrophic acetogens. In C. aceticum, however, the cytochrome is probably not involved in an electron transport chain that leads to proton translocation, as no genes for quinone biosynthesis are present in the genome. IMPORTANCE: Autotrophic acetogenic bacteria are receiving more and more industrial focus, as CO2 plus H2 as well as syngas are interesting new substrates for biotechnological processes. They are both cheap and abundant, and their use, if it results in sustainable products, also leads to reduction of greenhouse gases. Clostridium aceticum can use both gas mixtures, is phylogenetically not closely related to the commonly used species, and may thus become an even more attractive workhorse. In addition, its energy metabolism, which is characterized here, and the ability to synthesize cytochromes might offer new targets for improving the ATP yield by metabolic engineering and thus allow use of C. aceticum for production of compounds by pathways that currently present challenges for energy-limited acetogens.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.